Table 2.

The Effect of FcγRIIB1(B1) and FcγRIIB2 (B2) on Phagocytosis by the Chimeric Receptor FcγRIIIAα-γ-γ (EC-TM-CYT)

PIMFI
α-FcγRIIIα-FcγRII
Experiment 1  
 α-γ-γ  140  261  —  
 α-γ-γ + B1 127  227  104  
 α-γ-γ + B2  132  203 118  
Experiment 2  
 α-γ-γ  210  169  — 
 α-γ-γ + B1  198  140  102 
 α-γ-γ + B2  228  130  99  
Experiment 3 
 α-γ-γ  139  146  —  
 α-γ-γ + B1 103  149  149  
 α-γ-γ + B2  117  224 179  
Experiment 4  
 α-γ-γ  76  127  — 
 α-γ-γ + B1  63  128  128 
 α-γ-γ + B2  66  124  127 
PIMFI
α-FcγRIIIα-FcγRII
Experiment 1  
 α-γ-γ  140  261  —  
 α-γ-γ + B1 127  227  104  
 α-γ-γ + B2  132  203 118  
Experiment 2  
 α-γ-γ  210  169  — 
 α-γ-γ + B1  198  140  102 
 α-γ-γ + B2  228  130  99  
Experiment 3 
 α-γ-γ  139  146  —  
 α-γ-γ + B1 103  149  149  
 α-γ-γ + B2  117  224 179  
Experiment 4  
 α-γ-γ  76  127  — 
 α-γ-γ + B1  63  128  128 
 α-γ-γ + B2  66  124  127 

Four representative experiments are shown. The α-γ-γ chimera contains the EC of the FcγRIIIA α chain and the TM and CYT domains of the FcγRIIIA γ chain. B1 and B2 minimally inhibited α-γ-γ phagocytosis. Cell-surface expression of α-γ-γ was similar within each experiment and was not reduced by the expression of FcγRIIB. α-FcγRIII, anti-FcγRIII (recognizes α-γ-γ), α-FcγRII, anti-FcγRII (recognizes FcγRIIB).

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