Factors Associated With Individual Organ Toxicities and Posttransplant Fertility
| Target Organ* . | Covariate . | Values . | Univariate Relative Risk . | P Value . | 95% Confidence Interval . |
|---|---|---|---|---|---|
| Univariable Analysis | |||||
| Skin | Chronic GVHD† | No | 1.0 | — | — |
| Yes | 22.8 | <.001 | (5.41, 96.2) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 2.32 | .03 | (1.10, 4.91) | ||
| Buffy coat | No | 1.0 | — | — | |
| Yes | 1.98 | .07 | (0.94, 4.16) | ||
| Cataracts | Chronic GVHD | No | 1.0 | — | — |
| Yes | 5.87 | <.001 | (2.18, 15.8) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 3.69 | .002 | (1.63, 8.37) | ||
| Lung disease | Year of transplant‡ | Δ1 year | 1.06 | .06 | (1.00, 1.13) |
| Chronic GVHD | No | 1.0 | — | — | |
| Yes | 2.62 | .002 | (1.41, 4.88) | ||
| Buffy coat | No | 1.0 | — | — | |
| Yes | 2.08 | .02 | (1.13, 3.81) | ||
| CSP | No | 1.0 | — | — | |
| Yes | 1.78 | .08 | (0.94, 3.38) | ||
| Bone/joint disease | Chronic GVHD | No | 1.0 | — | — |
| Yes | 3.16 | .01 | (1.26, 7.92) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 2.08 | .11 | (0.86, 5.01) | ||
| Depression/suicide attempt | Chronic GVHD | No | 1.00 | — | — |
| Yes | 3.43 | .003 | (1.54, 7.66) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 3.08 | .003 | (1.46, 6.50) | ||
| Age at transplant‡ | Δ1 year | 1.06 | .006 | (1.02, 1.10) | |
| Buffy coat | No | 1.0 | — | — | |
| Yes | 1.96 | .08 | (0.93, 4.15) | ||
| Pregnancy2-153 | Year of transplant‡ | Δ1 year | 1.10 | .002 | (1.03, 1.16) |
| CSP | No | 1.0 | — | — | |
| Yes | 1.94 | .02 | (1.13, 3.33) | ||
| ATG | No | 1.0 | — | — | |
| Yes | 2.08 | .03 | (1.09, 3.97) | ||
| Multivariable Analysis | |||||
| Skin | Chronic GVHD† | No | 1.0 | — | — |
| Yes | 25.6 | <.001 | (5.99, 109.5) | ||
| CSP | No | 1.0 | — | — | |
| Yes | 3.11 | .05 | (1.03, 9.40) | ||
| Year of transplant‡ | Δ1 year | 0.87 | .03 | (0.77, 0.98) | |
| Cataracts | Chronic GVHD2-155 | No | 1.0 | — | — |
| Yes | 4.41 | .006 | (1.53, 12.7) | ||
| Acute GVHD2-155 | No | 1.0 | — | — | |
| Yes | 2.14 | .09 | (0.89, 5.15) | ||
| Year of transplant‡ | Δ1 year | 1.00 | .97 | (0.92, 1.08) | |
| Lung disease | Chronic GVHD | No | 1.0 | — | — |
| Yes | 3.08 | .001 | (1.60, 5.90) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 0.50 | .08 | (0.23, 1.08) | ||
| Year of transplant‡ | Δ1 year | 1.04 | .10 | (0.99, 1.13) | |
| Bone/joint disease | Chronic GVHD | No | 1.0 | — | — |
| Yes | 3.13 | .02 | (1.24, 7.88) | ||
| Year at transplant‡ | Δ1 year | 1.01 | .84 | (0.92, 1.11) | |
| Depression/suicide attempt | Chronic GVHD | No | 1.0 | — | — |
| Yes | 2.69 | .02 | (1.18, 6.16) | ||
| Age at transplant‡ | Δ1 year | 1.04 | .05 | (1.00, 1.08) | |
| Year of transplant‡ | Δ1 year | 1.05 | .23 | (0.97, 1.14) | |
| Pregnancy2-153 | Year of transplant‡ | Δ1 year | 1.10 | .002 | (1.03, 1.16) |
| Target Organ* . | Covariate . | Values . | Univariate Relative Risk . | P Value . | 95% Confidence Interval . |
|---|---|---|---|---|---|
| Univariable Analysis | |||||
| Skin | Chronic GVHD† | No | 1.0 | — | — |
| Yes | 22.8 | <.001 | (5.41, 96.2) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 2.32 | .03 | (1.10, 4.91) | ||
| Buffy coat | No | 1.0 | — | — | |
| Yes | 1.98 | .07 | (0.94, 4.16) | ||
| Cataracts | Chronic GVHD | No | 1.0 | — | — |
| Yes | 5.87 | <.001 | (2.18, 15.8) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 3.69 | .002 | (1.63, 8.37) | ||
| Lung disease | Year of transplant‡ | Δ1 year | 1.06 | .06 | (1.00, 1.13) |
| Chronic GVHD | No | 1.0 | — | — | |
| Yes | 2.62 | .002 | (1.41, 4.88) | ||
| Buffy coat | No | 1.0 | — | — | |
| Yes | 2.08 | .02 | (1.13, 3.81) | ||
| CSP | No | 1.0 | — | — | |
| Yes | 1.78 | .08 | (0.94, 3.38) | ||
| Bone/joint disease | Chronic GVHD | No | 1.0 | — | — |
| Yes | 3.16 | .01 | (1.26, 7.92) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 2.08 | .11 | (0.86, 5.01) | ||
| Depression/suicide attempt | Chronic GVHD | No | 1.00 | — | — |
| Yes | 3.43 | .003 | (1.54, 7.66) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 3.08 | .003 | (1.46, 6.50) | ||
| Age at transplant‡ | Δ1 year | 1.06 | .006 | (1.02, 1.10) | |
| Buffy coat | No | 1.0 | — | — | |
| Yes | 1.96 | .08 | (0.93, 4.15) | ||
| Pregnancy2-153 | Year of transplant‡ | Δ1 year | 1.10 | .002 | (1.03, 1.16) |
| CSP | No | 1.0 | — | — | |
| Yes | 1.94 | .02 | (1.13, 3.33) | ||
| ATG | No | 1.0 | — | — | |
| Yes | 2.08 | .03 | (1.09, 3.97) | ||
| Multivariable Analysis | |||||
| Skin | Chronic GVHD† | No | 1.0 | — | — |
| Yes | 25.6 | <.001 | (5.99, 109.5) | ||
| CSP | No | 1.0 | — | — | |
| Yes | 3.11 | .05 | (1.03, 9.40) | ||
| Year of transplant‡ | Δ1 year | 0.87 | .03 | (0.77, 0.98) | |
| Cataracts | Chronic GVHD2-155 | No | 1.0 | — | — |
| Yes | 4.41 | .006 | (1.53, 12.7) | ||
| Acute GVHD2-155 | No | 1.0 | — | — | |
| Yes | 2.14 | .09 | (0.89, 5.15) | ||
| Year of transplant‡ | Δ1 year | 1.00 | .97 | (0.92, 1.08) | |
| Lung disease | Chronic GVHD | No | 1.0 | — | — |
| Yes | 3.08 | .001 | (1.60, 5.90) | ||
| Acute GVHD | No | 1.0 | — | — | |
| Yes | 0.50 | .08 | (0.23, 1.08) | ||
| Year of transplant‡ | Δ1 year | 1.04 | .10 | (0.99, 1.13) | |
| Bone/joint disease | Chronic GVHD | No | 1.0 | — | — |
| Yes | 3.13 | .02 | (1.24, 7.88) | ||
| Year at transplant‡ | Δ1 year | 1.01 | .84 | (0.92, 1.11) | |
| Depression/suicide attempt | Chronic GVHD | No | 1.0 | — | — |
| Yes | 2.69 | .02 | (1.18, 6.16) | ||
| Age at transplant‡ | Δ1 year | 1.04 | .05 | (1.00, 1.08) | |
| Year of transplant‡ | Δ1 year | 1.05 | .23 | (0.97, 1.14) | |
| Pregnancy2-153 | Year of transplant‡ | Δ1 year | 1.10 | .002 | (1.03, 1.16) |
*No factor was significant for the development of a malignancy.
GVHD, graft-versus-host disease; CSP, cyclosporine; ATG, antithymocyte globulin.
By 1-year increments.
A pregnancy or fathered a pregnancy. Patients considered at risk after the age of 16.
Previous studies had shown that treatment of GVHD with steroids was the major risk factor.28 29