Laboratory Data of AvWD
| Case No. . | Diagnosis . | Age . | Sex . | Bleeding Tendency . | Inhibitor . | Blood Type . | Platelets (×104/ mm3) . | RIPA (%) . | VWF:AG (%) . | VWF: RCOF (%) . | VWF: AG/ VWF: RCOF . | F:VIII C (%) . | Bleeding Time (min) . | Treatment . | Response to Treatment . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CML | 46 | M | − | + | 0 | 59.9 | 3 | 27 | 20 | 1.35 | 16 | 12.0 | UD | Yes |
| 2 | 45 | M | − | − | A | 21.1 | 32 | 68 | 44 | 1.54 | 24 | 13.0 | UD + DDAVP | Yes | |
| 3 | 39 | F | − | − | B | 12.0 | 37 | 62 | 22 | 2.82 | 28 | 9.5 | UD | Yes | |
| 4 | 45 | F | − | − | A | 84.7 | 46* | 36 | 22 | 1.63 | 14 | 12.0 | UD | Yes | |
| 5 | 53 | M | − | − | A | 52.0 | 52* | ND | ND | ND | ND | ND | UD | Yes | |
| 6 | 46 | F | + | − | O | 61.0 | 55* | ND | ND | ND | ND | ND | UD | No | |
| 7 | 30 | M | − | − | A | 39.3 | 65* | 46 | 22 | 2.10 | 22 | 6.5 | UD | Yes | |
| 8 | 46 | M | − | − | B | 66.7 | 18 | 42 | 22 | 1.90 | 18 | 11.5 | UD + DDAVP | Yes | |
| 9 | PV | 83 | M | − | − | A | 60.7 | 16 | 121 | 40 | 3.03 | 38 | 10.0 | UD + DDAVP | Yes |
| 10 | 72 | F | + | + | A | 69.5 | 38* | 108 | 20 | 5.40 | 16 | 13.5 | UD + DDAVP | No | |
| 11 | 48 | F | − | − | B | 78.0 | 56* | 60 | 20 | 3.00 | 14 | 5.0 | UD | Yes | |
| 12 | ET | 67 | F | − | − | AB | 130.5 | 0 | ND | ND | ND | ND | 13.5 | UD | Yes |
| 13 | 72 | F | − | − | A | 119.5 | 76* | 65 | 40 | 1.63 | 26 | 9.0 | UD | Yes | |
| 14 | 58 | F | − | − | A | 124.8 | 73* | 68 | 36 | 1.89 | 24 | 10.5 | UD | Yes | |
| 15 | AML | 51 | F | + | + | O | 14.6 | 0 | 32 | 20 | 1.60 | 8 | ND | UD | No |
| 16 | 44 | F | − | − | AB | 12.0 | 7 | 62 | 22 | 2.82 | 18 | 12.5 | UD | Yes | |
| 17 | AMMoL | 67 | M | − | − | B | 11.9 | 0 | ND | ND | ND | ND | 10.5 | UD | Yes |
| 18 | ALL | 39 | M | − | − | A | 12.6 | 0 | 48 | 20 | 2.40 | 12 | ND | UD | Yes |
| 19 | MM IgG-λ | 43 | M | + | + | A | 37.8 | 0 | 28 | 5 | 5.60 | 6 | 15.5 | UD + DDAVP | No |
| 20 | IgG-κ | 62 | M | + | + | A | 24.3 | 4 | 32 | 9 | 3.56 | 8 | 15.0 | UD | Yes |
| 21 | IgG-λ | 49 | M | + | + | O | 42.6 | 7 | 7 | 4 | 1.75 | 10 | ND | UD | Yes |
| 22 | CLL IV | 64 | F | + | + | A | 23.3 | 21 | 36 | 12 | 3.00 | 15 | 10.5 | UD | No |
| 23 | IV | 85 | F | − | ND | B | 12.0 | 19 | 22 | 9 | 2.44 | 24 | 6.0 | UD + DDAVP | Yes |
| 24 | IV | 52 | F | − | + | A | 17.2 | 7 | 22 | 7 | 3.13 | 9 | 12.5 | UD | Yes |
| 25 | NHL | 48 | M | − | − | A | 34.8 | 46* | 69 | 34 | 2.03 | 38 | 6.5 | UD | Yes |
| Normal values | 15-34 | 40-80 | 50-155 | 80-120 | 0.9-1.3 | 80-120 | 4-8 |
| Case No. . | Diagnosis . | Age . | Sex . | Bleeding Tendency . | Inhibitor . | Blood Type . | Platelets (×104/ mm3) . | RIPA (%) . | VWF:AG (%) . | VWF: RCOF (%) . | VWF: AG/ VWF: RCOF . | F:VIII C (%) . | Bleeding Time (min) . | Treatment . | Response to Treatment . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CML | 46 | M | − | + | 0 | 59.9 | 3 | 27 | 20 | 1.35 | 16 | 12.0 | UD | Yes |
| 2 | 45 | M | − | − | A | 21.1 | 32 | 68 | 44 | 1.54 | 24 | 13.0 | UD + DDAVP | Yes | |
| 3 | 39 | F | − | − | B | 12.0 | 37 | 62 | 22 | 2.82 | 28 | 9.5 | UD | Yes | |
| 4 | 45 | F | − | − | A | 84.7 | 46* | 36 | 22 | 1.63 | 14 | 12.0 | UD | Yes | |
| 5 | 53 | M | − | − | A | 52.0 | 52* | ND | ND | ND | ND | ND | UD | Yes | |
| 6 | 46 | F | + | − | O | 61.0 | 55* | ND | ND | ND | ND | ND | UD | No | |
| 7 | 30 | M | − | − | A | 39.3 | 65* | 46 | 22 | 2.10 | 22 | 6.5 | UD | Yes | |
| 8 | 46 | M | − | − | B | 66.7 | 18 | 42 | 22 | 1.90 | 18 | 11.5 | UD + DDAVP | Yes | |
| 9 | PV | 83 | M | − | − | A | 60.7 | 16 | 121 | 40 | 3.03 | 38 | 10.0 | UD + DDAVP | Yes |
| 10 | 72 | F | + | + | A | 69.5 | 38* | 108 | 20 | 5.40 | 16 | 13.5 | UD + DDAVP | No | |
| 11 | 48 | F | − | − | B | 78.0 | 56* | 60 | 20 | 3.00 | 14 | 5.0 | UD | Yes | |
| 12 | ET | 67 | F | − | − | AB | 130.5 | 0 | ND | ND | ND | ND | 13.5 | UD | Yes |
| 13 | 72 | F | − | − | A | 119.5 | 76* | 65 | 40 | 1.63 | 26 | 9.0 | UD | Yes | |
| 14 | 58 | F | − | − | A | 124.8 | 73* | 68 | 36 | 1.89 | 24 | 10.5 | UD | Yes | |
| 15 | AML | 51 | F | + | + | O | 14.6 | 0 | 32 | 20 | 1.60 | 8 | ND | UD | No |
| 16 | 44 | F | − | − | AB | 12.0 | 7 | 62 | 22 | 2.82 | 18 | 12.5 | UD | Yes | |
| 17 | AMMoL | 67 | M | − | − | B | 11.9 | 0 | ND | ND | ND | ND | 10.5 | UD | Yes |
| 18 | ALL | 39 | M | − | − | A | 12.6 | 0 | 48 | 20 | 2.40 | 12 | ND | UD | Yes |
| 19 | MM IgG-λ | 43 | M | + | + | A | 37.8 | 0 | 28 | 5 | 5.60 | 6 | 15.5 | UD + DDAVP | No |
| 20 | IgG-κ | 62 | M | + | + | A | 24.3 | 4 | 32 | 9 | 3.56 | 8 | 15.0 | UD | Yes |
| 21 | IgG-λ | 49 | M | + | + | O | 42.6 | 7 | 7 | 4 | 1.75 | 10 | ND | UD | Yes |
| 22 | CLL IV | 64 | F | + | + | A | 23.3 | 21 | 36 | 12 | 3.00 | 15 | 10.5 | UD | No |
| 23 | IV | 85 | F | − | ND | B | 12.0 | 19 | 22 | 9 | 2.44 | 24 | 6.0 | UD + DDAVP | Yes |
| 24 | IV | 52 | F | − | + | A | 17.2 | 7 | 22 | 7 | 3.13 | 9 | 12.5 | UD | Yes |
| 25 | NHL | 48 | M | − | − | A | 34.8 | 46* | 69 | 34 | 2.03 | 38 | 6.5 | UD | Yes |
| Normal values | 15-34 | 40-80 | 50-155 | 80-120 | 0.9-1.3 | 80-120 | 4-8 |
Abbreviations: UD, Treatment of the underlying disease; RIPA, ristocetin-induced platelet aggregation; CML, chronic myelocytic leukemia; PV, polycythemia rubra vera; ET, essential thrombocythemia; AML, acute myelocytic leukemia; AMMoL, acute myelomonocytic leukemia; ALL, acute lymphocytic leukemia; MM, multiple myeloma; CLL, chronic lymphocytic leukemia; NHL, non-Hodgkin's lymphoma.
Dimunition in the slope of the response curve.