Clinico-Pathologic and Cytogenetic Features of the Lymphomas/Leukemias Investigated for the t(8;14) by FISH
| Case . | Sex . | Age (yr) . | Diagnosis . | Specimen Source . | Karyotype . | Percentage of t(8;14)+ Cells . | ||
|---|---|---|---|---|---|---|---|---|
| Cytogenetics . | FISH (Type I) . | FISH (Type II) . | ||||||
| BL1 | M | 28 | Burkitt NHL | Prostate | 46,XY,der(1)dup(1)(q42q21)add(1)(q21), t(8;14)(q24;q32)[18] | 100 | 100.0 | 100.0 |
| BL2 | M | 21 | Burkitt NHL | Bone marrow | 46,XY,t(8;14)(q24;q32)[6]/46,XY[15] | 29 | 36.5 | 49.5 |
| BL3 | M | 66 | Burkitt NHL | Bone marrow | 46,XY,t(8;14)(q24;q32),der(13)t(4;13) (q31;q34)[20]/47,idem,+12[4]/46,XY[2] | 92 | 15.5 | 37.5 |
| BL4 | M | 9 | Burkitt NHL | Peritoneal effusion | 46,XY,t(8;14)(q24;q32),add(13)(q24)[17] | 100 | 42.0 | 72.0 |
| BL5 | M | 50 | Burkitt NHL | Peritoneal effusion | 46,XY,dup(1)(q21q41),t(8;14)(q24;q32)[14] | 100 | 43.0 | 63.0 |
| BL6 | M | 12 | Burkitt NHL | Pleural effusion | 47,XY,t(8;14)(q24;q32),+12[2] | 100 | 33.3 | 88.0 |
| BL7 | M | 23 | Burkitt NHL | Lymph node | 46,inv(X)(p22q2?5),Y,t(8;14)(q24;q32)[18] | 100 | 4.3 | 14.3 |
| BL8 | M | 24 | Burkitt-like NHL | Lymph node | 51,XY,+5,+7,t(8;14)(q24;q32),+15, +19,+20[5]/46,XY[19] | 21 | 0.5 | 11.5 |
| BL9 | F | 76 | ALL-FAB L3 | Bone marrow | 46,XX,del(6)(q16q24),t(8;14)(q24;q32)[21]/46,idem,dup(1)(q32q22)[1] | 100 | 5.0 | 20.0 |
| BL10 | M | 9 | ALL-FAB L3 | Bone marrow | Failure | Failure | 54.5 | 58.1 |
| Case . | Sex . | Age (yr) . | Diagnosis . | Specimen Source . | Karyotype . | Percentage of t(8;14)+ Cells . | ||
|---|---|---|---|---|---|---|---|---|
| Cytogenetics . | FISH (Type I) . | FISH (Type II) . | ||||||
| BL1 | M | 28 | Burkitt NHL | Prostate | 46,XY,der(1)dup(1)(q42q21)add(1)(q21), t(8;14)(q24;q32)[18] | 100 | 100.0 | 100.0 |
| BL2 | M | 21 | Burkitt NHL | Bone marrow | 46,XY,t(8;14)(q24;q32)[6]/46,XY[15] | 29 | 36.5 | 49.5 |
| BL3 | M | 66 | Burkitt NHL | Bone marrow | 46,XY,t(8;14)(q24;q32),der(13)t(4;13) (q31;q34)[20]/47,idem,+12[4]/46,XY[2] | 92 | 15.5 | 37.5 |
| BL4 | M | 9 | Burkitt NHL | Peritoneal effusion | 46,XY,t(8;14)(q24;q32),add(13)(q24)[17] | 100 | 42.0 | 72.0 |
| BL5 | M | 50 | Burkitt NHL | Peritoneal effusion | 46,XY,dup(1)(q21q41),t(8;14)(q24;q32)[14] | 100 | 43.0 | 63.0 |
| BL6 | M | 12 | Burkitt NHL | Pleural effusion | 47,XY,t(8;14)(q24;q32),+12[2] | 100 | 33.3 | 88.0 |
| BL7 | M | 23 | Burkitt NHL | Lymph node | 46,inv(X)(p22q2?5),Y,t(8;14)(q24;q32)[18] | 100 | 4.3 | 14.3 |
| BL8 | M | 24 | Burkitt-like NHL | Lymph node | 51,XY,+5,+7,t(8;14)(q24;q32),+15, +19,+20[5]/46,XY[19] | 21 | 0.5 | 11.5 |
| BL9 | F | 76 | ALL-FAB L3 | Bone marrow | 46,XX,del(6)(q16q24),t(8;14)(q24;q32)[21]/46,idem,dup(1)(q32q22)[1] | 100 | 5.0 | 20.0 |
| BL10 | M | 9 | ALL-FAB L3 | Bone marrow | Failure | Failure | 54.5 | 58.1 |
The Burkitt translocation is indicated in bold face.
Abbreviations: M, male; F, female.