Incomplete List of Potential Specific Gene Inhibition Using Ribozymes
| Application . | Ribozyme Target . | Affect . | References . |
|---|---|---|---|
| Overcoming drug resistance | MDR-1 | ∼200-fold reduction in vincristine resistance | 70 |
| Reduction in mRNA | 71 | ||
| Overcoming transformed | H-ras (mutation) | Abrogation of tumorigenicity in nude mice | 72 |
| phenotype | Decrease in proliferation and differentiation in melanoma cells | 73 | |
| bcr-abl (translocation) | Decrease in cell proliferation | 74 | |
| Decrease in mRNA and protein levels | 75,76 | ||
| Decrease in tumorigenicity ofbcr-abl–transfected cells in nude mice | 77 | ||
| Pleiotrophin (growth factor) | Decrease in tumour growth, angiogenesis and metastasis | 78 | |
| Overcoming viral disease | HIV-1 | Increased resistance to HIV-1 infection | 79 |
| CD4(+) lymphocytes transduced with ribozymes has delayed reaction to viral challenge | 80 | ||
| Inhibition of HIV-1 replication | 81 | ||
| Hepatitis B and C virus | 82,83 | ||
| Overcoming arthritis | Stromelysin | mRNA reduced | 84 |
| Application . | Ribozyme Target . | Affect . | References . |
|---|---|---|---|
| Overcoming drug resistance | MDR-1 | ∼200-fold reduction in vincristine resistance | 70 |
| Reduction in mRNA | 71 | ||
| Overcoming transformed | H-ras (mutation) | Abrogation of tumorigenicity in nude mice | 72 |
| phenotype | Decrease in proliferation and differentiation in melanoma cells | 73 | |
| bcr-abl (translocation) | Decrease in cell proliferation | 74 | |
| Decrease in mRNA and protein levels | 75,76 | ||
| Decrease in tumorigenicity ofbcr-abl–transfected cells in nude mice | 77 | ||
| Pleiotrophin (growth factor) | Decrease in tumour growth, angiogenesis and metastasis | 78 | |
| Overcoming viral disease | HIV-1 | Increased resistance to HIV-1 infection | 79 |
| CD4(+) lymphocytes transduced with ribozymes has delayed reaction to viral challenge | 80 | ||
| Inhibition of HIV-1 replication | 81 | ||
| Hepatitis B and C virus | 82,83 | ||
| Overcoming arthritis | Stromelysin | mRNA reduced | 84 |