Comparison of the C-Type and R-Type Vanilloid Receptors Found on DRG Neurons
| . | C-Type . | R-Type . |
|---|---|---|
| Capsaicin (Kd) | 316 nmol/L | 4,900 nmol/L |
| Resiniferatoxin (Kd) | 1 nmol/L | 0.04 nmol/L |
| Cooperativity (Hill coefficient) | 0.9-1.2 | 1.5-2.0 |
| Capsazepine (Ki) | 290 nmol/L | 4,000 nmol/L |
| Ruthenium red (IC50) | 800 nmol/L | 14 nmol/L |
| 45Ca uptake | Yes | No |
| Desensitization | Yes | Yes |
| Toxicity | Yes | No |
| . | C-Type . | R-Type . |
|---|---|---|
| Capsaicin (Kd) | 316 nmol/L | 4,900 nmol/L |
| Resiniferatoxin (Kd) | 1 nmol/L | 0.04 nmol/L |
| Cooperativity (Hill coefficient) | 0.9-1.2 | 1.5-2.0 |
| Capsazepine (Ki) | 290 nmol/L | 4,000 nmol/L |
| Ruthenium red (IC50) | 800 nmol/L | 14 nmol/L |
| 45Ca uptake | Yes | No |
| Desensitization | Yes | Yes |
| Toxicity | Yes | No |
See Acs et al.10