Expression of BCL6 and Genes That Rearrange With It in Chromosomal Translocations in B-Cell Lines
| Cell Line . | Phenotype . | Gene Expression . | ||||||
|---|---|---|---|---|---|---|---|---|
| BCL6 . | IGH . | IGL . | IGHG3 . | TTF . | BOB1 . | H4 . | ||
| 697 | Pre-B (ALL) | − | −/+ | + | − | − | + | + |
| Ramos | B (sBL) | + | + | + | − | + | + | + |
| Bjab | B (eBL) | + | + | + | − | + | + | + |
| CB33(Kat) | Immunoblast (LCL) | − | + | + | + | + | + | + |
| RD(CMV) | Immunoblast (LCL) | − | + | + | + | + | + | + |
| U266 | Plasma cell (MM) | − | − | + | − | + | + | + |
| Skmm1 | Plasma cell (MM) | − | + | − | + | + | + | + |
| JJN3 | Plasma cell (MM) | − | − | − | + | + | + | + |
| XG-4 | Plasma cell (MM) | − | + | + | + | + | + | + |
| XG-7 | Plasma cell (MM) | − | − | − | − | + | + | + |
| XG-10 | Plasma cell (MM) | − | + | − | + | + | + | + |
| Cell Line . | Phenotype . | Gene Expression . | ||||||
|---|---|---|---|---|---|---|---|---|
| BCL6 . | IGH . | IGL . | IGHG3 . | TTF . | BOB1 . | H4 . | ||
| 697 | Pre-B (ALL) | − | −/+ | + | − | − | + | + |
| Ramos | B (sBL) | + | + | + | − | + | + | + |
| Bjab | B (eBL) | + | + | + | − | + | + | + |
| CB33(Kat) | Immunoblast (LCL) | − | + | + | + | + | + | + |
| RD(CMV) | Immunoblast (LCL) | − | + | + | + | + | + | + |
| U266 | Plasma cell (MM) | − | − | + | − | + | + | + |
| Skmm1 | Plasma cell (MM) | − | + | − | + | + | + | + |
| JJN3 | Plasma cell (MM) | − | − | − | + | + | + | + |
| XG-4 | Plasma cell (MM) | − | + | + | + | + | + | + |
| XG-7 | Plasma cell (MM) | − | − | − | − | + | + | + |
| XG-10 | Plasma cell (MM) | − | + | − | + | + | + | + |
Abbreviations: ALL, acute lymphoblastic leukemia; sBL, sporadic-type Burkitt's lymphoma; eBL, endemic-type Burkitt's lymphoma; LCL, EBV-immortalized lymphoblastoid cell line; MM, multiple myeloma.