Table 5. Incidence of and Risk Factors... | American Society of Hematology

Table 5.

Incidence of and Risk Factors for CNS Recurrence: Selected Studies With Univariate Analyses of Risk Factors

Author, Year, Reference	No. of Patients	Systemic Treatment Received^4-150	% CNS Disease^4-151	% CNS Involvement at Diagnosis	Subtypes Included	Risk Factors
Author, Year, Reference	No. of Patients	Systemic Treatment Received^4-150	% CNS Disease^4-151	% CNS Involvement at Diagnosis	Subtypes Included	Histology	Advanced Stage	B- Symptoms	No. of Extranodal Sites	Disease Sites	Age (yr)
Litam et al, 1979⁹	292	COP, CHOP-HOP, CHOP-BLeo	11	NS	All histologies	Diffuse > nodular DUL and LBL > other diffuse lymphoma	Yes	NE	NE	BM, other, extranodal	<35
Herman et al, 1979⁶	1039	COP, CHOP-HOP, CHOP-BLeo	5	1	All histologies	Diffuse > nodular DUL and LBL > other diffuse lymphoma	NE	NE	NE	NE	NE
Levitt et al, 1980⁷	592	COP, CHOP-BLeo	9	1.7	All histologies	Diffuse > nodular	Yes	NE	NE	Marrow	NE
Liang et al, 1990¹²	833	NS	6.1	NS	All histologies	HGL > IGL > LGL	Yes	Yes	NE	Orbit, testis, PB, bone, sinuses, BM	No
Bashir et al, 1991⁵	277	CAP-BOP	5.1	1.1	DMCL, DLCL, IBL	No	No	No	No	Epidural disease^‡	<60

Author, Year, Reference	No. of Patients	Systemic Treatment Received^4-150	% CNS Disease^4-151	% CNS Involvement at Diagnosis	Subtypes Included	Risk Factors
Author, Year, Reference	No. of Patients	Systemic Treatment Received^4-150	% CNS Disease^4-151	% CNS Involvement at Diagnosis	Subtypes Included	Histology	Advanced Stage	B- Symptoms	No. of Extranodal Sites	Disease Sites	Age (yr)
Litam et al, 1979⁹	292	COP, CHOP-HOP, CHOP-BLeo	11	NS	All histologies	Diffuse > nodular DUL and LBL > other diffuse lymphoma	Yes	NE	NE	BM, other, extranodal	<35
Herman et al, 1979⁶	1039	COP, CHOP-HOP, CHOP-BLeo	5	1	All histologies	Diffuse > nodular DUL and LBL > other diffuse lymphoma	NE	NE	NE	NE	NE
Levitt et al, 1980⁷	592	COP, CHOP-BLeo	9	1.7	All histologies	Diffuse > nodular	Yes	NE	NE	Marrow	NE
Liang et al, 1990¹²	833	NS	6.1	NS	All histologies	HGL > IGL > LGL	Yes	Yes	NE	Orbit, testis, PB, bone, sinuses, BM	No
Bashir et al, 1991⁵	277	CAP-BOP	5.1	1.1	DMCL, DLCL, IBL	No	No	No	No	Epidural disease^‡	<60

Abbreviations: NS, not specified; NE, not evaluated; HGL, high-grade lymphoma; IGL, intermediate-grade lymphoma; LGL, low-grade lymphoma; DUL, diffuse undifferentiated lymphoma; LBL, lymphoblastic lymphoma; DMCL, diffuse mixed-cell lymphoma; DLCL, diffuse large-cell lymphoma; IBL, immunoblastic lymphoma; PB, peripheral blood; BM, bone marrow.

F4-150

For details of chemotherapy-regimens, see references.

F4-151

The percentage of patients with CNS involvement. In most reports, this includes patients with CNS involvement at presentation. When specified, the percentage of patients with CNS involvement at presentation is shown in the next column.

‡

B-symptoms, histology, extranodal involvement, response to therapy and gender are not associated with risk for CNS recurrence.

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