Table 3.

Comparative Effect of 12 Polar Head Analogs on P falciparum Growth (IC50) and Lymphoblastoid Cell Viability (LV50)

Compounds IC50 (μmol/L) LV50(μmol/L)
E3  1.6  6.6  
E8  0.8  14  
F2  81.3 18,000  
F3  0.97  85  
F4  0.48  3.7  
F8 0.34  0.85  
F13  110  4,700  
G3  1.7  9,500 
G4  0.09  95  
G23  0.15  2,500  
H3  2 9,500  
HC3  4  7,000 
Compounds IC50 (μmol/L) LV50(μmol/L)
E3  1.6  6.6  
E8  0.8  14  
F2  81.3 18,000  
F3  0.97  85  
F4  0.48  3.7  
F8 0.34  0.85  
F13  110  4,700  
G3  1.7  9,500 
G4  0.09  95  
G23  0.15  2,500  
H3  2 9,500  
HC3  4  7,000 

LV50 were measured after 24 hours of drug contact with cells as described in the Materials and Methods. IC50against P falciparum are from Table 1.

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