Distribution of Mutations in VL Genes of HCV-Associated Lymphomas
| Patient . | VL Family . | Tumor Seq/ Clones Seq (source) . | VL Gene . | % Homology . | R:S Mutations . | P* . | JL Gene . | |
|---|---|---|---|---|---|---|---|---|
| SS | VKIII | 3/3 (PB) | kv325 | 98.9 | CDR | 0:0 | .49 | JK2 |
| FWR | 1:2 | .16 | ||||||
| SEG | VKIII | 4/6 (BM) 4/4 (PB) | kv325 | 97.4 | CDR FWR | 4:1 0:1 | .008 .005 | JK3 |
| LC2 | VKIII | 4/5 (PB) | kv325 | 98.9 | CDR | 2:0 | .11 | JK2 |
| FWR | 1:0 | .16 | ||||||
| LC3 | VKIII | 4/4 (PB) | kv325 | 99.3 | CDR | 1:0 | .27 | JK1 |
| FWR | 0:1 | .17 | ||||||
| HAZ | VKIII | 3/3 (PB) | kv325 | 99.3 | CDR | 0:1 | .7 | JK2 |
| FWR | 0:1 | .17 | ||||||
| LC4 | VKIII | 4/4 (PB) | Vg | 97.0 | CDR | 4:0 | .033 | JK3 |
| FWR | 1:3 | .004 | ||||||
| SEL | VKIV | 3/7 (LN) | DPK24 | 95.4 | CDR | 5:3 | .16 | JK4 |
| FWR | 4:0 | .02 | ||||||
| Patient . | VL Family . | Tumor Seq/ Clones Seq (source) . | VL Gene . | % Homology . | R:S Mutations . | P* . | JL Gene . | |
|---|---|---|---|---|---|---|---|---|
| SS | VKIII | 3/3 (PB) | kv325 | 98.9 | CDR | 0:0 | .49 | JK2 |
| FWR | 1:2 | .16 | ||||||
| SEG | VKIII | 4/6 (BM) 4/4 (PB) | kv325 | 97.4 | CDR FWR | 4:1 0:1 | .008 .005 | JK3 |
| LC2 | VKIII | 4/5 (PB) | kv325 | 98.9 | CDR | 2:0 | .11 | JK2 |
| FWR | 1:0 | .16 | ||||||
| LC3 | VKIII | 4/4 (PB) | kv325 | 99.3 | CDR | 1:0 | .27 | JK1 |
| FWR | 0:1 | .17 | ||||||
| HAZ | VKIII | 3/3 (PB) | kv325 | 99.3 | CDR | 0:1 | .7 | JK2 |
| FWR | 0:1 | .17 | ||||||
| LC4 | VKIII | 4/4 (PB) | Vg | 97.0 | CDR | 4:0 | .033 | JK3 |
| FWR | 1:3 | .004 | ||||||
| SEL | VKIV | 3/7 (LN) | DPK24 | 95.4 | CDR | 5:3 | .16 | JK4 |
| FWR | 4:0 | .02 | ||||||
*P is the probability for obtaining the observed number of R mutations by chance. The P values were determined with the binomial probability model by analyzing all mutations from each set of clonally related transcripts together (counting each mutation only once). However, the P values were not significantly different when each clone was analyzed separately (data not shown).