Clinical and Laboratory Characteristics of 42 Patients With Phospholipid-Dependent Inhibitors of Coagulation Classified According to Their Coagulation Profile
| . | Coagulation Profile . | P . | |
|---|---|---|---|
| dRVVT (n = 24) (%) . | KCT (n = 18) (%) . | ||
| Age (yrs) | |||
| Mean ± SD | 41.5 ± 12.8 | 47.5 ± 16.8 | NS |
| Median; range | 39; 19-70 | 43; 20-76 | |
| Sex | |||
| M/F | 8/16 | 0/18 | .0065 |
| Anti–β2-GPI antibodies | |||
| Cardiolipin in solid-phase | 24 (100) | 13 (72) | .0059 |
| Mean ± SD (GPL and/or MPL units) | 122 ± 61 | 46 ± 52 | .0001 |
| β2-GPI in solid-phase | 16 (67) | 7 (39) | NS |
| Associated diseases | 12 (50) | 10 (56) | NS |
| SLE/SLE-like | 5 | 4 | |
| Other autoimmune disorders | 4 | 2 | |
| Other diseases | 3 | 4 | |
| Thrombosis | 17 (71) | 4 (22) | .0018 |
| Venous | 13 | 2 | .004 |
| Arterial | 4 | 2 | |
| Recurrent abortions (≥2) | 6 (25) | 5 (28) | NS |
| Thrombocytopenia | 2 (8) | 5 (28) | NS |
| . | Coagulation Profile . | P . | |
|---|---|---|---|
| dRVVT (n = 24) (%) . | KCT (n = 18) (%) . | ||
| Age (yrs) | |||
| Mean ± SD | 41.5 ± 12.8 | 47.5 ± 16.8 | NS |
| Median; range | 39; 19-70 | 43; 20-76 | |
| Sex | |||
| M/F | 8/16 | 0/18 | .0065 |
| Anti–β2-GPI antibodies | |||
| Cardiolipin in solid-phase | 24 (100) | 13 (72) | .0059 |
| Mean ± SD (GPL and/or MPL units) | 122 ± 61 | 46 ± 52 | .0001 |
| β2-GPI in solid-phase | 16 (67) | 7 (39) | NS |
| Associated diseases | 12 (50) | 10 (56) | NS |
| SLE/SLE-like | 5 | 4 | |
| Other autoimmune disorders | 4 | 2 | |
| Other diseases | 3 | 4 | |
| Thrombosis | 17 (71) | 4 (22) | .0018 |
| Venous | 13 | 2 | .004 |
| Arterial | 4 | 2 | |
| Recurrent abortions (≥2) | 6 (25) | 5 (28) | NS |
| Thrombocytopenia | 2 (8) | 5 (28) | NS |
Abbreviation: NS, not significant.