Expression of Resistance Proteins in Childhood ALL, AML, and Normal Cells
| . | P-gp . | MRP . | LRP . | ||
|---|---|---|---|---|---|
| C219 . | MRK16 . | MRPm6 . | MRPr1 . | LRP56 . | |
| ALL | |||||
| Initial | 2.06 (1.63-2.60) | 3.36 (2.51-4.38) | 2.26 (1.98-2.62) | 2.87 (2.49-3.35) | 1.99 (1.64-2.34) |
| Relapse | 2.32 (1.51-2.86) | 3.01 (2.38-3.74) | 2.25 (1.83-2.70) | 2.96 (2.64-3.44) | 2.30 (1.76-3.01) |
| AML | |||||
| Initial | 2.09 (1.38-2.66) | 2.01 (1.76-2.59) | 1.94 (1.68-2.18) | 2.32 (1.50-2.89) | 3.91 (2.86-7.39) |
| Relapse | 1.76 (1.67-2.46) | 2.28 (2.10-2.64) | 2.23 (1.86-2.46) | 2.85 (1.64-3.31) | 2.49 (2.09-2.92) |
| Normal cells | |||||
| PB lymphocytes | 1.88 (1.49-2.01) | 3.24 (2.74-4.06) | 1.88 (1.55-2.02) | 2.70 (2.18-2.99) | 5.14 (4.25-7.22) |
| BM-150 | 1.52/1.82 | 1.57/2.87/3.31 | NT | 1.27/1.35/1.93 | 1.86/2.33/2.37 |
| . | P-gp . | MRP . | LRP . | ||
|---|---|---|---|---|---|
| C219 . | MRK16 . | MRPm6 . | MRPr1 . | LRP56 . | |
| ALL | |||||
| Initial | 2.06 (1.63-2.60) | 3.36 (2.51-4.38) | 2.26 (1.98-2.62) | 2.87 (2.49-3.35) | 1.99 (1.64-2.34) |
| Relapse | 2.32 (1.51-2.86) | 3.01 (2.38-3.74) | 2.25 (1.83-2.70) | 2.96 (2.64-3.44) | 2.30 (1.76-3.01) |
| AML | |||||
| Initial | 2.09 (1.38-2.66) | 2.01 (1.76-2.59) | 1.94 (1.68-2.18) | 2.32 (1.50-2.89) | 3.91 (2.86-7.39) |
| Relapse | 1.76 (1.67-2.46) | 2.28 (2.10-2.64) | 2.23 (1.86-2.46) | 2.85 (1.64-3.31) | 2.49 (2.09-2.92) |
| Normal cells | |||||
| PB lymphocytes | 1.88 (1.49-2.01) | 3.24 (2.74-4.06) | 1.88 (1.55-2.02) | 2.70 (2.18-2.99) | 5.14 (4.25-7.22) |
| BM-150 | 1.52/1.82 | 1.57/2.87/3.31 | NT | 1.27/1.35/1.93 | 1.86/2.33/2.37 |
Values represent the median FI and the 25th and 75th percentiles (in parentheses), which are based on 101 to 112 initial ALL, 23 to 29 relapsed ALL, 13 to 20 initial AML, 5 to 7 relapsed AML, and 8 to 14 normal PB samples. Initial versus relapsed AML: LRP56, P = .041. Initial ALL versus initial AML: MRK16, P < .001; MRPm6,P = .007; MRPr1, P = .01; LRP56, P < .001. Initial ALL versus normal PB lymphocytes: MRPm6, P = .008; LRP56, P < .001.
Abbreviation: NT, not tested.
The FI of 2 to 3 normal BM samples are listed.