Correlation Between Expression of Resistance Proteins and Immunophenotype, WBC, and Age in Childhood ALL at Initial Diagnosis
| . | P-gp . | MRP . | LRP . | ||
|---|---|---|---|---|---|
| C219 . | MRK16 . | MRPm6 . | MRPr1 . | LRP56 . | |
| Immunophenotype | |||||
| Common/preB | 2.21 (1.75-2.71) | 3.40 (2.52-4.43) | 2.24 (1.92-2.60) | 2.81 (2.42-3.16) | 2.08 (1.78-2.54) |
| T | 1.67 (1.48-1.78) | 3.11 (2.29-3.97) | 2.35 (2.04-2.78) | 3.49 (3.15-3.82) | 1.49 (1.37-1.65) |
| WBC | |||||
| <25/nL | 2.29 (1.75-2.81) | 3.51 (2.76-4.84) | 2.15 (1.90-2.54) | 2.96 (2.69-3.35) | 2.00 (1.75-2.38) |
| ≥25/nL | 1.89 (1.54-2.42) | 3.28 (2.34-3.97) | 2.35 (2.04-2.67) | 2.86 (2.41-3.35) | 1.98 (1.53-2.50) |
| Age (mo) | |||||
| ≥12-<120 | 2.20 (1.75-2.63) | 3.36 (2.52-4.06) | 2.23 (1.92-2.62) | 2.86 (2.49-3.34) | 2.01 (1.68-2.34) |
| ≥120 | 1.69 (1.42-2.15) | 3.15 (2.26-4.72) | 2.37 (2.07-2.62) | 3.08 (2.48-3.50) | 1.88 (1.57-2.28) |
| . | P-gp . | MRP . | LRP . | ||
|---|---|---|---|---|---|
| C219 . | MRK16 . | MRPm6 . | MRPr1 . | LRP56 . | |
| Immunophenotype | |||||
| Common/preB | 2.21 (1.75-2.71) | 3.40 (2.52-4.43) | 2.24 (1.92-2.60) | 2.81 (2.42-3.16) | 2.08 (1.78-2.54) |
| T | 1.67 (1.48-1.78) | 3.11 (2.29-3.97) | 2.35 (2.04-2.78) | 3.49 (3.15-3.82) | 1.49 (1.37-1.65) |
| WBC | |||||
| <25/nL | 2.29 (1.75-2.81) | 3.51 (2.76-4.84) | 2.15 (1.90-2.54) | 2.96 (2.69-3.35) | 2.00 (1.75-2.38) |
| ≥25/nL | 1.89 (1.54-2.42) | 3.28 (2.34-3.97) | 2.35 (2.04-2.67) | 2.86 (2.41-3.35) | 1.98 (1.53-2.50) |
| Age (mo) | |||||
| ≥12-<120 | 2.20 (1.75-2.63) | 3.36 (2.52-4.06) | 2.23 (1.92-2.62) | 2.86 (2.49-3.34) | 2.01 (1.68-2.34) |
| ≥120 | 1.69 (1.42-2.15) | 3.15 (2.26-4.72) | 2.37 (2.07-2.62) | 3.08 (2.48-3.50) | 1.88 (1.57-2.28) |
Values represent the median FI and the 25th and 75th percentiles (in parentheses), which are based on the following number of ALL samples at initial diagnosis: 80 to 90 common/preB, 19 to 20 T-ALL, 40 to 47 WBC <25/nL, 57 to 62 WBC ≥25/nL, 73 to 80 age ≥12 to <120 months, and 25 to 28 age ≥120 months. Common/preB versus T-ALL: C219,P = .001; MRPr1, P < .001; LRP56, P < .001. Age between 12 and 120 months versus ≥120 months: C219, P = .016.