Cytogenetic Analysis of FAA Lymphoblast Cell Lines
| Cell Line . | Condition* . | Radials†‡ . | Breakageρ . |
|---|---|---|---|
| HSC 72 | −MMC | 0/15 | 3/15 |
| HSC 72 | +MMC | 7/15 | 15/15 |
| HSC 72/Retro | −MMC | 0/50 | 0/50 |
| HSC 72/Retro | +MMC | 4/50 | 15/50 |
| EUFA 528 | −MMC | 0/45 | 1/45 |
| EUFA 528 | +MMC | 23/45 | 39/45 |
| EUFA 528/Retro | −MMC | 0/45 | 2/45 |
| EUFA 528/Retro | +MMC | 0/45 | 2/45 |
| Lymphoblasts-NML2-155 | −MMC | 0/50 | 0/50 |
| Lymphoblasts-NML | +MMC | 0/50 | 0/50 |
| Cell Line . | Condition* . | Radials†‡ . | Breakageρ . |
|---|---|---|---|
| HSC 72 | −MMC | 0/15 | 3/15 |
| HSC 72 | +MMC | 7/15 | 15/15 |
| HSC 72/Retro | −MMC | 0/50 | 0/50 |
| HSC 72/Retro | +MMC | 4/50 | 15/50 |
| EUFA 528 | −MMC | 0/45 | 1/45 |
| EUFA 528 | +MMC | 23/45 | 39/45 |
| EUFA 528/Retro | −MMC | 0/45 | 2/45 |
| EUFA 528/Retro | +MMC | 0/45 | 2/45 |
| Lymphoblasts-NML2-155 | −MMC | 0/50 | 0/50 |
| Lymphoblasts-NML | +MMC | 0/50 | 0/50 |
Cells were incubated in the absence or presence of 40 ng/mL MMC for 36 hours.
The number of exchange figures (radials)/number of metaphases analyzed.
Greater than 20% radial formation is diagnostic for FA.
ρ Number of chromosome/chromatid gaps, fragments, and radials/number of metaphases analyzed.
Normal lymphoblasts.