DNA Index of BMPC and Results of Single Interphase FISH Study in Patients, at Diagnosis [a] and at Follow-Up [b]
| Pt No. . | Next Sample After (mo) . | Ig Peak . | BMPC (%) . | DNA Index of BMPC . | Single Interphase FISH Two (=D), Three (=T), or Four (=TT) Signals Within BMPC (% affected cells) . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Chr No. 3 . | Chr No. 7 . | Chr No. 9 . | Chr No. 11 . |
| 1.a | GK | 4 | 0.98 | D | D | D | D | |
| b | 12 | 1 | 1.00 | D | D | D | D | |
| 2.a | GL | 2 | 0.99 | D | D | D | D | |
| b | 23 | 3 | 1.00 | D | D | D | D | |
| 3.a | GK | 6 | 1.02 | D | D | D | D | |
| b | 27 | 3 | 0.99 | D | D | D | D | |
| 4.a | GL | 7 | 0.99 | D | D | D | D | |
| b | 26 | 6 | 0.98 | D | D | D | T (22%) | |
| 5.a | GK + GL | 1 | 1.01 | D | D | D | D | |
| b | 27 | 2 | 0.99 | D | D | T (15%) | D | |
| 6.a | GK | 4 | 0.98 | D | D | D | T (51%) | |
| b | 16 | 1 | 0.96 | D | D | D | T (48%) | |
| 7.a | AL | 2 | 1.01 | T (25%) | T (24%) | D | D | |
| b | 35 | 2 | 1.07 | T (45%) | T (53%) | D | D | |
| 8.a | GK | 3 | 0.97 | T (10%) | T (11%) | T (12%) | D | |
| b | 12 | 2 | 1.02 | T (10%) | T (9%) | T (12%) | D | |
| 9.a | GL | 3 | 1.11 | D | D | T (50%) | T (72%) | |
| b | 26 | 3 | 1.11 | nd | nd | T (62%) | T (73%) | |
| 10.a | GK | 3 | 0.99 | D | D | D | D | |
| b | 30 | 2 | 1.05 | T (14%) | D | T (22%) | T (26%) | |
| 11.a | GK | 4 | 1.17 | T (78%) | D | T (52%) | T (62%) | |
| b | 12 | 5 | 1.15 | T (74%) | D | T (45%) | T (50%) | |
| 12.a | GK | 2 | 1.12 | T (70%) | T (56%) | T (39%) | D | |
| b | 24 | 2 | 1.12 | T (63%) | T (62%) | T (40%) | D | |
| 13.a | AL | 5 | 0.99 | T (17%) | T (15%) | D | D | |
| b | 27 | 8 | 0.98 | T (56%) | T (44%) | T (44%) | T (39%) | |
| 14.a | GK | 1 | 0.99 | D | D | T (17%) | T (25%) | |
| b | 35 | 1 | 1.04 | T (19%) | D | T (21%) | D | |
| 15.a | GK | 5 | 1.07 | T (76%) | T (63%) | T (62%) | D | |
| b | 24 | 1 | 1.13 | T (72%) | T (66%) | T (51%) | D | |
| 16.a | GK | 3 | 1.13 | T (61%) | T (44%) | T (43%) | T (55%) | |
| b | 23 | 1 | 1.12 | T (51%) | T (43%) | T (38%) | T (43%) | |
| 17.a | GK | 1 | 1.13 | T (51%) | T (33%) | T (42%) | T (54%) | |
| b | 32 | 4 | 1.12 | T (65%) | T (53%) | T (57%) | T (61%) | |
| 18. | GK | 5 | 1.13 | T (58%) | T (61%) | D | T (67%) | |
| 19.* | GL | 4 | 1.45 | T + TT (75%) | T + TT (83%) | T + TT (62%) | T + TT (81%) | |
| Pt No. . | Next Sample After (mo) . | Ig Peak . | BMPC (%) . | DNA Index of BMPC . | Single Interphase FISH Two (=D), Three (=T), or Four (=TT) Signals Within BMPC (% affected cells) . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Chr No. 3 . | Chr No. 7 . | Chr No. 9 . | Chr No. 11 . |
| 1.a | GK | 4 | 0.98 | D | D | D | D | |
| b | 12 | 1 | 1.00 | D | D | D | D | |
| 2.a | GL | 2 | 0.99 | D | D | D | D | |
| b | 23 | 3 | 1.00 | D | D | D | D | |
| 3.a | GK | 6 | 1.02 | D | D | D | D | |
| b | 27 | 3 | 0.99 | D | D | D | D | |
| 4.a | GL | 7 | 0.99 | D | D | D | D | |
| b | 26 | 6 | 0.98 | D | D | D | T (22%) | |
| 5.a | GK + GL | 1 | 1.01 | D | D | D | D | |
| b | 27 | 2 | 0.99 | D | D | T (15%) | D | |
| 6.a | GK | 4 | 0.98 | D | D | D | T (51%) | |
| b | 16 | 1 | 0.96 | D | D | D | T (48%) | |
| 7.a | AL | 2 | 1.01 | T (25%) | T (24%) | D | D | |
| b | 35 | 2 | 1.07 | T (45%) | T (53%) | D | D | |
| 8.a | GK | 3 | 0.97 | T (10%) | T (11%) | T (12%) | D | |
| b | 12 | 2 | 1.02 | T (10%) | T (9%) | T (12%) | D | |
| 9.a | GL | 3 | 1.11 | D | D | T (50%) | T (72%) | |
| b | 26 | 3 | 1.11 | nd | nd | T (62%) | T (73%) | |
| 10.a | GK | 3 | 0.99 | D | D | D | D | |
| b | 30 | 2 | 1.05 | T (14%) | D | T (22%) | T (26%) | |
| 11.a | GK | 4 | 1.17 | T (78%) | D | T (52%) | T (62%) | |
| b | 12 | 5 | 1.15 | T (74%) | D | T (45%) | T (50%) | |
| 12.a | GK | 2 | 1.12 | T (70%) | T (56%) | T (39%) | D | |
| b | 24 | 2 | 1.12 | T (63%) | T (62%) | T (40%) | D | |
| 13.a | AL | 5 | 0.99 | T (17%) | T (15%) | D | D | |
| b | 27 | 8 | 0.98 | T (56%) | T (44%) | T (44%) | T (39%) | |
| 14.a | GK | 1 | 0.99 | D | D | T (17%) | T (25%) | |
| b | 35 | 1 | 1.04 | T (19%) | D | T (21%) | D | |
| 15.a | GK | 5 | 1.07 | T (76%) | T (63%) | T (62%) | D | |
| b | 24 | 1 | 1.13 | T (72%) | T (66%) | T (51%) | D | |
| 16.a | GK | 3 | 1.13 | T (61%) | T (44%) | T (43%) | T (55%) | |
| b | 23 | 1 | 1.12 | T (51%) | T (43%) | T (38%) | T (43%) | |
| 17.a | GK | 1 | 1.13 | T (51%) | T (33%) | T (42%) | T (54%) | |
| b | 32 | 4 | 1.12 | T (65%) | T (53%) | T (57%) | T (61%) | |
| 18. | GK | 5 | 1.13 | T (58%) | T (61%) | D | T (67%) | |
| 19.* | GL | 4 | 1.45 | T + TT (75%) | T + TT (83%) | T + TT (62%) | T + TT (81%) | |
Abbreviation: nd, not done.
For patient no. 19, 10% to 25% BMPC exhibited 4 signals (=TT) after hybridization, and results within brackets include BMPC with 3 + 4 signals.