Incidence of Tumor Growth and Regression in Athymic Mice Injected With EBV-Converted BL30 and BL41 Cell Lines
| Cell Line . | EBV Status . | Tumors/ Mice Injected . | Days to Tumor Appearance . | Days to Tumor Regression . | Regressing Tumors . | % Regression . | Maximum Size (cm2) . |
|---|---|---|---|---|---|---|---|
| BL30 | |||||||
| Parental | − | 10/10 | 18 ± 6.3 | — | 0/10 | 0.0 | — |
| P3HR-1 | + | 5/5 | 16 ± 0.0 | — | 0/5 | 0.0 | — |
| B95-8 | + | 5/5 | 30 ± 11 | 73 ± 15 | 5/5 | 100 | 3.1 ± 1.3 |
| Parental + B95-8 | −/+ | 5/5 | 20 ± 0.0 | 61 ± 10 | 4/5 | 80 | 4.3 ± 0.6 |
| BL41 | |||||||
| Parental | − | 8/8 | 11 ± 4.7 | — | 0/8 | 0.0 | — |
| P3HR-1 | + | 10/10 | 17 ± 8.0 | — | 0/10 | 0.0 | — |
| B95-8 | + | 8/9 | 34 ± 17 | 68 ± 36 | 7/8 | 87 | 5.4 ± 2.6 |
| Parental + B95-8 | −/+ | 5/5 | 11 ± 5.8 | 52 ± 0.0 | 2/5 | 40 | 6.5 ± 3.3 |
| Cell Line . | EBV Status . | Tumors/ Mice Injected . | Days to Tumor Appearance . | Days to Tumor Regression . | Regressing Tumors . | % Regression . | Maximum Size (cm2) . |
|---|---|---|---|---|---|---|---|
| BL30 | |||||||
| Parental | − | 10/10 | 18 ± 6.3 | — | 0/10 | 0.0 | — |
| P3HR-1 | + | 5/5 | 16 ± 0.0 | — | 0/5 | 0.0 | — |
| B95-8 | + | 5/5 | 30 ± 11 | 73 ± 15 | 5/5 | 100 | 3.1 ± 1.3 |
| Parental + B95-8 | −/+ | 5/5 | 20 ± 0.0 | 61 ± 10 | 4/5 | 80 | 4.3 ± 0.6 |
| BL41 | |||||||
| Parental | − | 8/8 | 11 ± 4.7 | — | 0/8 | 0.0 | — |
| P3HR-1 | + | 10/10 | 17 ± 8.0 | — | 0/10 | 0.0 | — |
| B95-8 | + | 8/9 | 34 ± 17 | 68 ± 36 | 7/8 | 87 | 5.4 ± 2.6 |
| Parental + B95-8 | −/+ | 5/5 | 11 ± 5.8 | 52 ± 0.0 | 2/5 | 40 | 6.5 ± 3.3 |
BALB/c nu/nu mice were injected subcutaneously with 107 cells (in 0.2 mL RPMI 1640), from the indicated exponentially growing parental P3HR-1–converted or B95-8–converted BL30 or BL41 cell lines. Groups of mice were also injected with a mixture of parental EBV− BL cells (BL30 or BL41 cell lines, 107 cells) and the EBV-B95-8–converted BL cells (BL30-B95-8 and BL41-B95-8, 107 cells). Experimental conditions and evaluation are described in the legend to Table 1.