Surface Phenotype of PBMC From Subjects Examined
| . | % Total Cells Staining . | % High Efflux . | % Low Efflux . |
|---|---|---|---|
| CD3 | 59, 61, 58 (59) | 29, 29, 27 (28) | 24, 31, 24 (26) |
| CD14 | 12, 13, 15 (13) | 0, 0, 0 (0) | 9, 10, 14 (11) |
| CD22 | 15, 11, 12 (13) | 1, 1, 1 (1) | 10, 12, 10 (11) |
| . | % Total Cells Staining . | % High Efflux . | % Low Efflux . |
|---|---|---|---|
| CD3 | 59, 61, 58 (59) | 29, 29, 27 (28) | 24, 31, 24 (26) |
| CD14 | 12, 13, 15 (13) | 0, 0, 0 (0) | 9, 10, 14 (11) |
| CD22 | 15, 11, 12 (13) | 1, 1, 1 (1) | 10, 12, 10 (11) |
The surface phenotype of PBMC in HTLV-I–infected subjects (subjects no. 4 and 5 [asymptomatic] and no. 7 [HAM/TSP]) were examined. The percentage of cells staining with MoAbs against CD3 (T-cell marker), CD14 (monocyte-macrophage cell marker), and CD22 (B-cell marker) are shown (mean frequency in parentheses). In each case, almost all of the cells in the high efflux population are T cells, whereas the low efflux P-gp negative population of cells contains a mixture of T cells, B cells, and monocyte-macrophages.