Table 4. CD8 expansions in age-matched... | American Society of Hematology

Table 4.

CD8⁺ expansions in age-matched controls and multiple myeloma patients

	Age-matched controls	Patients with MM^4-150
No. subjects in study	27	22
No. subjects with CD8⁺ expansions^4-151	16	21
Total no. CD8⁺ expansions^4-151	23	71
Mean no. CD8⁺ expansions per positive subject^4-151	1.4	3.4
No. subjects with CD8⁺ expansions predicted to be detectable by Southern blot^‡	4	13
Total no. CD8⁺ expansions predicted to be detectable by Southern blot^‡	5	25
No. CD8⁺ expansions predicted to be detectable by Southern blot per positive subject^‡	1.3	1.9
Total no. CD8⁺expansions^4-151,^4-153	20	35

	Age-matched controls	Patients with MM^4-150
No. subjects in study	27	22
No. subjects with CD8⁺ expansions^4-151	16	21
Total no. CD8⁺ expansions^4-151	23	71
Mean no. CD8⁺ expansions per positive subject^4-151	1.4	3.4
No. subjects with CD8⁺ expansions predicted to be detectable by Southern blot^‡	4	13
Total no. CD8⁺ expansions predicted to be detectable by Southern blot^‡	5	25
No. CD8⁺ expansions predicted to be detectable by Southern blot per positive subject^‡	1.3	1.9
Total no. CD8⁺expansions^4-151,^4-153	20	35

Data were calculated as a function of total CD3⁺cells, except where noted otherwise.

MM indicates multiple myeloma.

F4-150

Reanalyzed data of 22 patients with MM from previous publication.5

F4-151

After gating for CD8⁺CD3⁺ T cells, expanded populations were those calculated as a function of total CD3⁺ cells and that present at 3 SD or more above the mean percentage of V_β⁺CD8⁺ cells of the age-matched controls.

‡

The size of monoclonal V_β⁺populations (predicted to be detectable by Southern blot) was estimated by subtracting the mean values for the particular V_β from the percentage of CD8⁺CD3⁺ T cells, calculated as above.

F4-153

Calculated as a function of total CD8⁺ cells.

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