Type of the First Thrombotic Event and Age at the Time of Development for the 116 Symptomatic Relatives
| . | Total . | Coagulation Defect . | |||||
|---|---|---|---|---|---|---|---|
| No Defect . | Antithrombin Deficiency . | Protein C Deficiency . | Protein S Deficiency . | Factor V Leiden . | Double Defects . | ||
| Symptomatic relatives/total relatives (%) | 116/723 (16%) | 15/327 (5%) | 30/85 (35%) | 19/64 (30%) | 15/41 (37%) | 35/200 (18%) | 2/6 (33%) |
| Symptomatic men/women | 45/71 | 5/10 | 16/14 | 5/14 | 10/5 | 7/28 | 2/0 |
| Relatives with venous thrombosis/total relatives (%) | 99/723 (14%) | 9/327 (3%) | 30/85 (35%) | 16/64 (25%) | 12/41 (29%) | 30/200 (15%) | 2/6 (33%) |
| Venous thromboembolism | 74/99 (75%) | 3/9 (33%) | 27/30 (90%) | 14/16 (88%) | 12/12 (100%) | 17/30 (57%) | 1/2 (50%) |
| Superficial vein thrombosis | 25/99 (25%) | 6/9 (67%) | 3/30 (10%) | 2/16 (13%) | 0/12 | 13/30 (43%) | 1/2 (50%) |
| Relatives with arterial thrombosis/total relatives (%) | 17/723 (2%) | 6/327 (2%) | 0/85 | 3/64 (5%) | 3/41 (7%) | 5/200 (3%) | 0/6 |
| Age at thrombosis (yr), mean ± SD Range | 34 ± 14 10-80 | 40 ± 14* 21-62 | 35 ± 15 10-77 | 40 ± 9* 20-58 | 40 ± 15 20-67 | 37 ± 15 15-80 | 17 ± 2 15-19 |
| . | Total . | Coagulation Defect . | |||||
|---|---|---|---|---|---|---|---|
| No Defect . | Antithrombin Deficiency . | Protein C Deficiency . | Protein S Deficiency . | Factor V Leiden . | Double Defects . | ||
| Symptomatic relatives/total relatives (%) | 116/723 (16%) | 15/327 (5%) | 30/85 (35%) | 19/64 (30%) | 15/41 (37%) | 35/200 (18%) | 2/6 (33%) |
| Symptomatic men/women | 45/71 | 5/10 | 16/14 | 5/14 | 10/5 | 7/28 | 2/0 |
| Relatives with venous thrombosis/total relatives (%) | 99/723 (14%) | 9/327 (3%) | 30/85 (35%) | 16/64 (25%) | 12/41 (29%) | 30/200 (15%) | 2/6 (33%) |
| Venous thromboembolism | 74/99 (75%) | 3/9 (33%) | 27/30 (90%) | 14/16 (88%) | 12/12 (100%) | 17/30 (57%) | 1/2 (50%) |
| Superficial vein thrombosis | 25/99 (25%) | 6/9 (67%) | 3/30 (10%) | 2/16 (13%) | 0/12 | 13/30 (43%) | 1/2 (50%) |
| Relatives with arterial thrombosis/total relatives (%) | 17/723 (2%) | 6/327 (2%) | 0/85 | 3/64 (5%) | 3/41 (7%) | 5/200 (3%) | 0/6 |
| Age at thrombosis (yr), mean ± SD Range | 34 ± 14 10-80 | 40 ± 14* 21-62 | 35 ± 15 10-77 | 40 ± 9* 20-58 | 40 ± 15 20-67 | 37 ± 15 15-80 | 17 ± 2 15-19 |
*P = .04 compared with double defects.