Action of various nucleoside analogs on formation and removal of oxaliplatin ICL in the DHFR gene of CLL lymphocytes
. | ICL/10, kb* . | Removal, %† . | Removal inhibition, %‡ . |
|---|---|---|---|
| Fludarabine | 40 | ||
| Without | 0.62 | 85 | |
| With | 1.16 | 51 | |
| Cytarabine | 14 | ||
| Without | 0.64 | 78 | |
| With | 0.79 | 67 | |
| Clofarabine | 63 | ||
| Without | 0.65 | 81 | |
| With | 1.41 | 30 |
. | ICL/10, kb* . | Removal, %† . | Removal inhibition, %‡ . |
|---|---|---|---|
| Fludarabine | 40 | ||
| Without | 0.62 | 85 | |
| With | 1.16 | 51 | |
| Cytarabine | 14 | ||
| Without | 0.64 | 78 | |
| With | 0.79 | 67 | |
| Clofarabine | 63 | ||
| Without | 0.65 | 81 | |
| With | 1.41 | 30 |
Values represent ICL/10 kb in the DHFR gene from CLL cells incubated with 400 μM oxaliplatin for 7 hours.
Values represent percentage of ICL removal at 8 hours.
Values represent percentage of inhibition of ICL removal at 8 hours. Data are from at least 3 blots each of 3 independent biologic experiments.