Top up- or down-regulated genes in lkL/L BM pDCs
Gene name . | Gene symbol . | Fold change, log2 . |
|---|---|---|
| Up-regulated genes | ||
| Neural cell adhesion molecule 1 (CD56)* | Ncam1 | 8.04 |
| Sulfatase 2* | Sulf2 | 7.58 |
| Troponin T2, cardiac* | Tnnt2 | 7.12 |
| Myosin 1B* | Myo1b | 6.77 |
| Low-density lipoprotein receptor-related protein 1 | Lrp1 | 6.24 |
| Immunoglobulin lambda-like polypeptide 1 (lambda 5)* | Igll1 | 6.17 |
| Von Willebrand factor homolog* | Vwf | 5.66 |
| RIKEN cDNA D030029J20 gene* | D030029J20Rik | 5.54 |
| Cytochrome P450, family 2, subfamily j, polypeptide 6* | Cyp2j6 | 5.48 |
| Matrix metallopeptidase 14 (membrane inserted)* | Mmp14 | 5.20 |
| Lipoma HMGIC fusion partner* | Lhfp | 5.03 |
| Lipoma HMGIC fusion partner-like 2* | Lhfp12 | 5.00 |
| Serologically defined colon cancer antigen 33-like* | MG1:2153084 | 5.00 |
| Pre-B lymphocyte gene 1 | Vpreb1 | 4.96 |
| Dedicator of cytokinesis 1 | Dock1 | 4.90 |
| C1q and tumor necrosis factor-related protein 1* | Clqtnf1 | 4.83 |
| Catenin (cadherin associated protein), delta 1* | Ctnnd1 | 4.67 |
| Uveal autoantigen with coiled-coil domains and ankyrin repeats* | Uaca | 4.58 |
| Protein phosphatase 1, regulatory (inhibitor) subunit 9A* | Ppplr9a | 4.48 |
| Interleukin-18 receptor 1* | Il18r1 | 4.33 |
| SAM and SH3 domain-containing 1* | Sash1 | 4.18 |
| Parathyroid hormone receptor 1* | Pthr1 | 4.10 |
| AXL receptor tyrosine kinase* | Axl | 4.07 |
| FK506 binding protein 9* | Fkbp9 | 4.06 |
| RIKEN cDNA 4732416N19 gene* | 4732416N19Rik | 4.04 |
| Lymphocyte protein tyrosine kinase* | Lck | 4.01 |
| Fibroblast growth factor 13* | Fgfl3 | 4.00 |
| DNA segment, Chr 15, ERATO Doi 366, expressed* | D15Erid366e | 3.92 |
| Sulfotransferase family 1A, phenol-preferring, member 1* | Sultlal | 3.92 |
| cDNA sequence BC031593* | BC031593 | 3.88 |
| Solute carrier family 27 (fatty acid transporter), member 3* | Slc27a3 | 3.87 |
| Retinoic acid-induced 14* | Rail4 | 3.86 |
| Nerve growth factor receptor (TNFR superfamily, member 16) | Ngfr | 3.81 |
| Selenoprotein M* | MG1:2149786 | 3.76 |
| T-cell receptor beta, variable 13* | Tcrb-V13 | 3.73 |
| Heterogeneous nuclear ribonucleoprotein L-like | Hnrpll | 3.72 |
| Protein kinase C, theta* | Prkcq | 3.67 |
| RIKEN cDNAC730015A04 gene* | C730015A04Rik | 3.60 |
| Fucosyltransferase 10, mRNA* | Fut10 | 3.59 |
| Nuclear receptor subfamily 1, group H, member 4 (FXR)* | Nrlh4 | 3.57 |
| Cytochrome P450, family 7, subfamily b, polypeptide 1 | Cyp7b1 | 3.57 |
| Cadherin 22 | Cdh22 | 3.54 |
| Ajuba* | Jub | 3.53 |
| Kit ligand* | Kitl | 3.47 |
| Galectin-related interfiber protein* | Grifin | 3.46 |
| Hairy and enhancer of split 1 | Hes1 | 3.44 |
| Epithelial membrane protein 1* | Emp1 | 3.42 |
| Cyclin D2 | Ccnd2 | 3.31 |
| RIKEN cDNA B230206N24 gene* | B230206N24Rik | 3.23 |
| Dedicator of cytokinesis 9* | Dock9 | 3.20 |
| Serine (or cysteine) peptidase inhibitor, clade H, member 1 | Serpinh1 | 3.17 |
| Dynamin 1* | Dnml | 3.17 |
| RIKEN cDNA 2010300C02 gene* | 2010300C02Rik | 3.16 |
| cDNA sequence BC025600 | BC025600 | 3.14 |
| ATP-binding cassette transporter subfamily A member 9 | Abca9 | 3.08 |
| Nuclear factor I/X | Nfix | 3.03 |
| SH3-domain binding protein 5 (BTK-associated) | Sh3bp5 | 3.01 |
| Prion protein | Prnp | 3.01 |
| Down-regulated genes | ||
| Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF* | Obscn | -4.06 |
| CD22 antigen | Cd22 | -3.26 |
| Paired-Ig-like receptor A1 | Pira1 | -2.93 |
| Odd Oz/ten-m homolog 4 (Drosophila)* | Odz4 | -2.92 |
| Regulator of G-protein signaling 1 | Rgs1 | -2.82 |
| GTP binding protein (gene overexpressed in skeletal muscle) | Gem | -2.68 |
| G-protein-coupled receptor 65 | Gpr65 | -2.67 |
| Sterile alpha motif domain containing 9-like | Samd91 | -2.67 |
| Killer cell lectinlike receptor, subfamily A, member 17 (Ly49Q) | Klra17 | -2.52 |
| Hypothetical protein 9530028C05 | 9530028C05 | -2.47 |
| Hydroxysteroid 11-beta dehydrogenase 1 | Hsd11b1 | -2.47 |
| Paired-Ig-like receptor A2 | Pira2 | -2.42 |
| CD8 antigen, beta chain 1 | Cd8b1 | -2.39 |
| Expressed sequence A1447904 | A1447904 | -2.36 |
| ATPase, Na+/K+ trasporting, alpha 3 polypeptide | Atpla3 | -2.32 |
| cDNA sequence BC022623 | BC022623 | -2.29 |
| Properdin factor, complement | Pfc | -2.19 |
| Serine (or cysteine) peptidase inhibitor, clade 1, member 1 | Serpinil | -2.12 |
| CEA-related cell adhesion molecule 1 | Ceacam1 | -2.10 |
| Chemokine (C-C motif) receptor 9 | Ccr9 | -2.07 |
Gene name . | Gene symbol . | Fold change, log2 . |
|---|---|---|
| Up-regulated genes | ||
| Neural cell adhesion molecule 1 (CD56)* | Ncam1 | 8.04 |
| Sulfatase 2* | Sulf2 | 7.58 |
| Troponin T2, cardiac* | Tnnt2 | 7.12 |
| Myosin 1B* | Myo1b | 6.77 |
| Low-density lipoprotein receptor-related protein 1 | Lrp1 | 6.24 |
| Immunoglobulin lambda-like polypeptide 1 (lambda 5)* | Igll1 | 6.17 |
| Von Willebrand factor homolog* | Vwf | 5.66 |
| RIKEN cDNA D030029J20 gene* | D030029J20Rik | 5.54 |
| Cytochrome P450, family 2, subfamily j, polypeptide 6* | Cyp2j6 | 5.48 |
| Matrix metallopeptidase 14 (membrane inserted)* | Mmp14 | 5.20 |
| Lipoma HMGIC fusion partner* | Lhfp | 5.03 |
| Lipoma HMGIC fusion partner-like 2* | Lhfp12 | 5.00 |
| Serologically defined colon cancer antigen 33-like* | MG1:2153084 | 5.00 |
| Pre-B lymphocyte gene 1 | Vpreb1 | 4.96 |
| Dedicator of cytokinesis 1 | Dock1 | 4.90 |
| C1q and tumor necrosis factor-related protein 1* | Clqtnf1 | 4.83 |
| Catenin (cadherin associated protein), delta 1* | Ctnnd1 | 4.67 |
| Uveal autoantigen with coiled-coil domains and ankyrin repeats* | Uaca | 4.58 |
| Protein phosphatase 1, regulatory (inhibitor) subunit 9A* | Ppplr9a | 4.48 |
| Interleukin-18 receptor 1* | Il18r1 | 4.33 |
| SAM and SH3 domain-containing 1* | Sash1 | 4.18 |
| Parathyroid hormone receptor 1* | Pthr1 | 4.10 |
| AXL receptor tyrosine kinase* | Axl | 4.07 |
| FK506 binding protein 9* | Fkbp9 | 4.06 |
| RIKEN cDNA 4732416N19 gene* | 4732416N19Rik | 4.04 |
| Lymphocyte protein tyrosine kinase* | Lck | 4.01 |
| Fibroblast growth factor 13* | Fgfl3 | 4.00 |
| DNA segment, Chr 15, ERATO Doi 366, expressed* | D15Erid366e | 3.92 |
| Sulfotransferase family 1A, phenol-preferring, member 1* | Sultlal | 3.92 |
| cDNA sequence BC031593* | BC031593 | 3.88 |
| Solute carrier family 27 (fatty acid transporter), member 3* | Slc27a3 | 3.87 |
| Retinoic acid-induced 14* | Rail4 | 3.86 |
| Nerve growth factor receptor (TNFR superfamily, member 16) | Ngfr | 3.81 |
| Selenoprotein M* | MG1:2149786 | 3.76 |
| T-cell receptor beta, variable 13* | Tcrb-V13 | 3.73 |
| Heterogeneous nuclear ribonucleoprotein L-like | Hnrpll | 3.72 |
| Protein kinase C, theta* | Prkcq | 3.67 |
| RIKEN cDNAC730015A04 gene* | C730015A04Rik | 3.60 |
| Fucosyltransferase 10, mRNA* | Fut10 | 3.59 |
| Nuclear receptor subfamily 1, group H, member 4 (FXR)* | Nrlh4 | 3.57 |
| Cytochrome P450, family 7, subfamily b, polypeptide 1 | Cyp7b1 | 3.57 |
| Cadherin 22 | Cdh22 | 3.54 |
| Ajuba* | Jub | 3.53 |
| Kit ligand* | Kitl | 3.47 |
| Galectin-related interfiber protein* | Grifin | 3.46 |
| Hairy and enhancer of split 1 | Hes1 | 3.44 |
| Epithelial membrane protein 1* | Emp1 | 3.42 |
| Cyclin D2 | Ccnd2 | 3.31 |
| RIKEN cDNA B230206N24 gene* | B230206N24Rik | 3.23 |
| Dedicator of cytokinesis 9* | Dock9 | 3.20 |
| Serine (or cysteine) peptidase inhibitor, clade H, member 1 | Serpinh1 | 3.17 |
| Dynamin 1* | Dnml | 3.17 |
| RIKEN cDNA 2010300C02 gene* | 2010300C02Rik | 3.16 |
| cDNA sequence BC025600 | BC025600 | 3.14 |
| ATP-binding cassette transporter subfamily A member 9 | Abca9 | 3.08 |
| Nuclear factor I/X | Nfix | 3.03 |
| SH3-domain binding protein 5 (BTK-associated) | Sh3bp5 | 3.01 |
| Prion protein | Prnp | 3.01 |
| Down-regulated genes | ||
| Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF* | Obscn | -4.06 |
| CD22 antigen | Cd22 | -3.26 |
| Paired-Ig-like receptor A1 | Pira1 | -2.93 |
| Odd Oz/ten-m homolog 4 (Drosophila)* | Odz4 | -2.92 |
| Regulator of G-protein signaling 1 | Rgs1 | -2.82 |
| GTP binding protein (gene overexpressed in skeletal muscle) | Gem | -2.68 |
| G-protein-coupled receptor 65 | Gpr65 | -2.67 |
| Sterile alpha motif domain containing 9-like | Samd91 | -2.67 |
| Killer cell lectinlike receptor, subfamily A, member 17 (Ly49Q) | Klra17 | -2.52 |
| Hypothetical protein 9530028C05 | 9530028C05 | -2.47 |
| Hydroxysteroid 11-beta dehydrogenase 1 | Hsd11b1 | -2.47 |
| Paired-Ig-like receptor A2 | Pira2 | -2.42 |
| CD8 antigen, beta chain 1 | Cd8b1 | -2.39 |
| Expressed sequence A1447904 | A1447904 | -2.36 |
| ATPase, Na+/K+ trasporting, alpha 3 polypeptide | Atpla3 | -2.32 |
| cDNA sequence BC022623 | BC022623 | -2.29 |
| Properdin factor, complement | Pfc | -2.19 |
| Serine (or cysteine) peptidase inhibitor, clade 1, member 1 | Serpinil | -2.12 |
| CEA-related cell adhesion molecule 1 | Ceacam1 | -2.10 |
| Chemokine (C-C motif) receptor 9 | Ccr9 | -2.07 |
Genes that up-regulated more than 3 logs or down-regulated more than 2 logs are shown. Fold change values correspond to the average of the values for all the IkL/L/WT comparisons.
Genes that are absent in all WT (ie, up-regulated genes in IkL/L samples) or IkL/L (ie, down-regulated genes in IkL/L samples) samples.