Risk of myocardial infarction with increasing quintile of factor XIc and factor XIIc overall and in men younger than age 50
. | Patients . | Control subjects . | OR (95% CI)* . | OR (95% CI)† . | OR (95% CI)‡ . |
|---|---|---|---|---|---|
| Factor XIc | |||||
| Overall, N | 560 | 646 | |||
| 55%-94% | 69 | 133 | 1§ | 1§ | 1§ |
| 95%-103% | 117 | 136 | 1.7 (1.1-2.4) | 1.9 (1.3-2.7) | 2.0 (1.0-3.8) |
| 104%-112% | 117 | 121 | 1.8 (1.2-2.7) | 2.2 (1.5-3.4) | 2.7 (1.4-5.3) |
| 113%-126% | 132 | 128 | 2.0 (1.3-2.9) | 2.9 (1.9-4.4) | 2.7 (1.4-5.3) |
| 127%-194% | 125 | 128 | 1.8 (1.2-2.7) | 3.2 (2.1-4.9) | 2.5 (1.2-5.1) |
| Younger than 50 y, no. | 154 | 160 | |||
| 55%-94% | 9 | 34 | 1§ | 1§ | 1§ |
| 95%-103% | 31 | 31 | 3.4 (1.4-8.4) | 4.2 (1.7-10.7) | 12.7 (1.4-113.6) |
| 104%-112% | 39 | 31 | 4.1 (1.7-9.9) | 5.5 (2.1-14.0) | 19.5 (2.1-178.0) |
| 113%-126% | 30 | 29 | 3.3 (1.3-8.3) | 4.4 (1.7-11.5) | 14.8 (1.6-136.1) |
| 127%-194% | 45 | 35 | 4.4 (1.9-10.5) | 6.6 (2.5-17.3) | 19.0 (2.0-182.0) |
| Factor XIIc | |||||
| Overall, N | 560 | 646 | |||
| 23%-79% | 144 | 132 | 1§ | 1§ | 1§ |
| 80%-95% | 133 | 132 | 0.9 (0.6-1.3) | 0.8 (0.5-1.1) | 1.0 (0.6-1.8) |
| 96%-106% | 132 | 122 | 1.0 (0.7-1.4) | 0.8 (0.5-1.1) | 1.0 (0.6-1.7) |
| 107%-118% | 95 | 131 | 0.6 (0.4-0.9) | 0.5 (0.3-0.7) | 0.7 (0.4-1.3) |
| 119%-164% | 56 | 129 | 0.4 (0.2-0.5) | 0.2 (0.1-0.4) | 0.3 (0.1-0.6) |
| Younger than 50 y, no. | 154 | 160 | |||
| 23%-79% | 29 | 32 | 1§ | 1§ | 1§ |
| 80%-95% | 38 | 33 | 1.2 (0.6-2.4) | 1.1 (0.5-2.3) | 0.7 (0.2-2.0) |
| 96%-106% | 33 | 28 | 1.3 (0.6-2.8) | 1.1 (0.5-2.3) | 0.9 (0.3-2.7) |
| 107%-118% | 30 | 31 | 1.1 (0.5-2.2) | 0.8 (0.4-1.7) | 1.0 (0.4-2.7) |
| 119%-164% | 24 | 36 | 0.7 (0.4-1.5) | 0.4 (0.2-1.0) | 0.3 (0.1-1.0) |
. | Patients . | Control subjects . | OR (95% CI)* . | OR (95% CI)† . | OR (95% CI)‡ . |
|---|---|---|---|---|---|
| Factor XIc | |||||
| Overall, N | 560 | 646 | |||
| 55%-94% | 69 | 133 | 1§ | 1§ | 1§ |
| 95%-103% | 117 | 136 | 1.7 (1.1-2.4) | 1.9 (1.3-2.7) | 2.0 (1.0-3.8) |
| 104%-112% | 117 | 121 | 1.8 (1.2-2.7) | 2.2 (1.5-3.4) | 2.7 (1.4-5.3) |
| 113%-126% | 132 | 128 | 2.0 (1.3-2.9) | 2.9 (1.9-4.4) | 2.7 (1.4-5.3) |
| 127%-194% | 125 | 128 | 1.8 (1.2-2.7) | 3.2 (2.1-4.9) | 2.5 (1.2-5.1) |
| Younger than 50 y, no. | 154 | 160 | |||
| 55%-94% | 9 | 34 | 1§ | 1§ | 1§ |
| 95%-103% | 31 | 31 | 3.4 (1.4-8.4) | 4.2 (1.7-10.7) | 12.7 (1.4-113.6) |
| 104%-112% | 39 | 31 | 4.1 (1.7-9.9) | 5.5 (2.1-14.0) | 19.5 (2.1-178.0) |
| 113%-126% | 30 | 29 | 3.3 (1.3-8.3) | 4.4 (1.7-11.5) | 14.8 (1.6-136.1) |
| 127%-194% | 45 | 35 | 4.4 (1.9-10.5) | 6.6 (2.5-17.3) | 19.0 (2.0-182.0) |
| Factor XIIc | |||||
| Overall, N | 560 | 646 | |||
| 23%-79% | 144 | 132 | 1§ | 1§ | 1§ |
| 80%-95% | 133 | 132 | 0.9 (0.6-1.3) | 0.8 (0.5-1.1) | 1.0 (0.6-1.8) |
| 96%-106% | 132 | 122 | 1.0 (0.7-1.4) | 0.8 (0.5-1.1) | 1.0 (0.6-1.7) |
| 107%-118% | 95 | 131 | 0.6 (0.4-0.9) | 0.5 (0.3-0.7) | 0.7 (0.4-1.3) |
| 119%-164% | 56 | 129 | 0.4 (0.2-0.5) | 0.2 (0.1-0.4) | 0.3 (0.1-0.6) |
| Younger than 50 y, no. | 154 | 160 | |||
| 23%-79% | 29 | 32 | 1§ | 1§ | 1§ |
| 80%-95% | 38 | 33 | 1.2 (0.6-2.4) | 1.1 (0.5-2.3) | 0.7 (0.2-2.0) |
| 96%-106% | 33 | 28 | 1.3 (0.6-2.8) | 1.1 (0.5-2.3) | 0.9 (0.3-2.7) |
| 107%-118% | 30 | 31 | 1.1 (0.5-2.2) | 0.8 (0.4-1.7) | 1.0 (0.4-2.7) |
| 119%-164% | 24 | 36 | 0.7 (0.4-1.5) | 0.4 (0.2-1.0) | 0.3 (0.1-1.0) |
Adjusted for age.
Adjusted for age and either factor XIIc or factor XIc, each as continuous factor.
Adjusted for age, either factor XIIc or factor XIc each as a continuous factor; total cholesterol, HDL-cholesterol, and triglyceride levels; quetelet index; smoking; alcohol use; and diabetes, excluding persons having hypertension.
Reference group.