Table 4

Adoptive transfer of Ptpn11D61Y BM and spleen cells

Donor cellsLong-term multilineage reconstitution*MPDT-ALL
Bone marrow 0/12 0/12 3/12 
Spleen 6/10 0/10 3/10 
Donor cellsLong-term multilineage reconstitution*MPDT-ALL
Bone marrow 0/12 0/12 3/12 
Spleen 6/10 0/10 3/10 
*

Presence of donor-derived CD4+/8+ cells, B220+ cells, and Gr1+ cells at 24 weeks after transplantation.

Two mice developed recipient-derived T-ALL and one died of donor-derived T-ALL.

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