Univariate hazard ratios and C-statistic values for lymphocyte count and other prognostic variables
| . | Time to treatment . | Overall survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| n (events) . | C-statistic (SE) . | HR (95% CI) . | Difference in time to treatment, P . | n (events) . | C-statistic (SE) . | HR (95% CI) . | Difference in survival, P . | |
| B-cell count ≥ 11 vs < 11 × 109/L | 456 (51) | 0.64 (0.04) | 3.02 (1.74-5.23) | <.001 | 459 (42) | 0.60 (0.05) | 2.36 (1.28-4.36) | .01 |
| ALC ≥ 12 vs < 12 × 109/L | 456 (51) | 0.62 (0.04) | 2.28 (1.31-3.97) | .003 | 459 (42) | 0.56 (0.04) | 1.62 (0.89-2.99) | .12 |
| CD38 | 435 (48) | 0.64 (0.04) | 3.21 (1.82-5.70) | <.001 | 438 (37) | 0.56 (0.04) | 2.17 (1.10-4.25) | .03 |
| ZAP-70 | 275 (22) | 0.76 (0.05) | 5.82 (2.48-13.66) | <.001 | 278 (9) | 0.51 (0.09) | 2.77 (0.74-10.37) | .14 |
| IGHV (unmutated) | 274 (35) | 0.72 (0.04) | 6.25 (3.03-12.5) | <.001 | 277 (17) | 0.62 (0.07) | 2.86 (1.10-7.69) | .03 |
| FISH | 297 (34) | 0.58 (0.04) | 3.48 (1.51-8.01) | .01 | 299 (15) | 0.59 (0.08) | 4.47 (1.52-13.12) | .01 |
| Favorable (normal, 13q−, +12) | ||||||||
| Unfavorable (17p−, 11q−) | ||||||||
| . | Time to treatment . | Overall survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| n (events) . | C-statistic (SE) . | HR (95% CI) . | Difference in time to treatment, P . | n (events) . | C-statistic (SE) . | HR (95% CI) . | Difference in survival, P . | |
| B-cell count ≥ 11 vs < 11 × 109/L | 456 (51) | 0.64 (0.04) | 3.02 (1.74-5.23) | <.001 | 459 (42) | 0.60 (0.05) | 2.36 (1.28-4.36) | .01 |
| ALC ≥ 12 vs < 12 × 109/L | 456 (51) | 0.62 (0.04) | 2.28 (1.31-3.97) | .003 | 459 (42) | 0.56 (0.04) | 1.62 (0.89-2.99) | .12 |
| CD38 | 435 (48) | 0.64 (0.04) | 3.21 (1.82-5.70) | <.001 | 438 (37) | 0.56 (0.04) | 2.17 (1.10-4.25) | .03 |
| ZAP-70 | 275 (22) | 0.76 (0.05) | 5.82 (2.48-13.66) | <.001 | 278 (9) | 0.51 (0.09) | 2.77 (0.74-10.37) | .14 |
| IGHV (unmutated) | 274 (35) | 0.72 (0.04) | 6.25 (3.03-12.5) | <.001 | 277 (17) | 0.62 (0.07) | 2.86 (1.10-7.69) | .03 |
| FISH | 297 (34) | 0.58 (0.04) | 3.48 (1.51-8.01) | .01 | 299 (15) | 0.59 (0.08) | 4.47 (1.52-13.12) | .01 |
| Favorable (normal, 13q−, +12) | ||||||||
| Unfavorable (17p−, 11q−) | ||||||||