Adjusted hazard ratios for lymphocyte count and other prognostic variables
| . | Treatment-free survival . | Overall survival . | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | C-statistic . | HR (95% CI) . | P . | C-statistic . | |
| 0.72 | 0.65 | |||||
| CD38+ | 3.20 (1.80-5.66) | .001 | 2.14 (1.09-4.20) | .04 | ||
| B cell ≥ 11 | 3.10 (1.76-5.47) | .001 | 2.63 (1.37-5.03) | .001 | ||
| 0.85 | 0.67 | |||||
| ZAP+ | 8.33 (3.37-20.61) | <.001 | 2.88 (0.77-10.79) | .13 | ||
| B cell ≥11 | 6.86 (2.77-17.01) | <.001 | 3.41 (0.85-13.71) | .09 | ||
| 0.78 | 0.63 | |||||
| Unmutated | 5.26 (2.56-11.11) | <.001 | 2.38 (0.88-6.25) | .08 | ||
| B cell ≥ 11 | 3.06 (1.54-6.07) | .001 | 2.54 (0.94-6.81) | .07 | ||
| 0.73 | 0.74 | |||||
| FISH (17p− or 11q−) | 3.97 (2.00-7.88) | .01 | 3.63 (1.22-10.76) | .03 | ||
| B cell ≥ 11 | 3.67 (1.58-8.50) | <.001 | 3.61 (1.25-10.48) | .02 | ||
| . | Treatment-free survival . | Overall survival . | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | C-statistic . | HR (95% CI) . | P . | C-statistic . | |
| 0.72 | 0.65 | |||||
| CD38+ | 3.20 (1.80-5.66) | .001 | 2.14 (1.09-4.20) | .04 | ||
| B cell ≥ 11 | 3.10 (1.76-5.47) | .001 | 2.63 (1.37-5.03) | .001 | ||
| 0.85 | 0.67 | |||||
| ZAP+ | 8.33 (3.37-20.61) | <.001 | 2.88 (0.77-10.79) | .13 | ||
| B cell ≥11 | 6.86 (2.77-17.01) | <.001 | 3.41 (0.85-13.71) | .09 | ||
| 0.78 | 0.63 | |||||
| Unmutated | 5.26 (2.56-11.11) | <.001 | 2.38 (0.88-6.25) | .08 | ||
| B cell ≥ 11 | 3.06 (1.54-6.07) | .001 | 2.54 (0.94-6.81) | .07 | ||
| 0.73 | 0.74 | |||||
| FISH (17p− or 11q−) | 3.97 (2.00-7.88) | .01 | 3.63 (1.22-10.76) | .03 | ||
| B cell ≥ 11 | 3.67 (1.58-8.50) | <.001 | 3.61 (1.25-10.48) | .02 | ||
Top row in each pair indicates the HR of the listed prognostic factor after controlling for B-cell count. The bottom row in each pair indicates the HR for B-cell count after controlling for the prognostic variable listed in row above.