Table 2

Multivariable analysis for relapse-free survival

Relative risk95% CI
Significance, P value
Lower limitUpper limit
CD40, median 94% or more vs less than median 94% 0.15 0.03 0.72 .018 
Leukocytes, less than 50×109/L vs 50×109/L or more 0.78 0.19 3.18 .73 
Age, younger than 10 y vs 10 y or older 0.74 0.16 3.56 .71 
PVA score, 5 to 7 vs 8 + 9
 		0.38
 		0.08
 		1.90
 		.24
 
CD40, median 94% or more vs less than median 94% 0.40 0.15 1.08 .072 
LR vs HR 0.84 0.33 2.12 .71 
Late relapse only 
    CD40, median 94% or more vs less than median 94% 0.16 0.03 0.72 .018 
    LR vs HR 1.02 0.32 3.30 .97 
Relative risk95% CI
Significance, P value
Lower limitUpper limit
CD40, median 94% or more vs less than median 94% 0.15 0.03 0.72 .018 
Leukocytes, less than 50×109/L vs 50×109/L or more 0.78 0.19 3.18 .73 
Age, younger than 10 y vs 10 y or older 0.74 0.16 3.56 .71 
PVA score, 5 to 7 vs 8 + 9
 		0.38
 		0.08
 		1.90
 		.24
 
CD40, median 94% or more vs less than median 94% 0.40 0.15 1.08 .072 
LR vs HR 0.84 0.33 2.12 .71 
Late relapse only 
    CD40, median 94% or more vs less than median 94% 0.16 0.03 0.72 .018 
    LR vs HR 1.02 0.32 3.30 .97 

Multivariable analysis was performed to determine the relative impact of prognostic parameters for risk of relapse (n = 121). To calculate the impact of the risk factors on late relapse-free survival only, any patient who was not alive without relapse at 2 years after study entry was excluded for Cox regression analysis (n = 108). Thus, for relapse-free survival, CD40 expression but not clinical risk parameters or risk group affiliation has as impact on outcome particularly when focusing on late relapse.

LR indicates low risk, and HR, high risk.

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