Table 1 Clinical and laboratory features... | American Society of Hematology

Table 1

Clinical and laboratory features of patients with CLL

Patient no.	Sex	Age, y	Rai stage	ZAP70*	FISH†	TP53
1	F	82	1	Absent/low	13q−	Mut (exon V)
2	M	66	4	Interm/high	ND	WT
3	M	65	1	Absent/low	Nor	WT
4	M	68	4	Interm/high	12+	WT
5	F	62	0	Absent/low	Nor	WT
6	M	64	1	Absent/low	13q−/11q−	WT
7	M	67	2	Interm/high	17p−	WT
8	F	78	2	Absent/low	11q−	WT
9	M	51	0	Absent/low	Nor	WT
10	F	59	0	Absent/low	Nor	WT
11	M	69	2	Absent/low	13q−/17p−	WT
12	M	40	4	Interm/high	11q−	WT
13	M	74	2	Interm/high	13q−	WT
14	M	62	4	Interm/high	17p−	WT
15	M	62	0	Absent/low	11q−	WT
16	M	69	2	Absent/low	17p−	Mut (exon VII)
17	F	79	3	Absent/low	12+	WT
18	M	61	2	Interm/high	17p−	WT
19	M	63	4	Absent/low	13q−	WT
20	M	60	4	Absent/low	17p−	WT
21	M	59	2	Absent/low	13q−	WT
22	M	64	1	Interm/high	13q−	WT
23	M	57	1	Absent/low	12+	WT
24	M	67	4	ND	ND	WT
25	F	68	2	Interm/high	17p−	Mut (exon V)
26	F	55	0	Absent/low	ND	WT
27	M	61	2	Absent/low	17p−	Mut (exon VI)

Patient no.	Sex	Age, y	Rai stage	ZAP70*	FISH†	TP53
1	F	82	1	Absent/low	13q−	Mut (exon V)
2	M	66	4	Interm/high	ND	WT
3	M	65	1	Absent/low	Nor	WT
4	M	68	4	Interm/high	12+	WT
5	F	62	0	Absent/low	Nor	WT
6	M	64	1	Absent/low	13q−/11q−	WT
7	M	67	2	Interm/high	17p−	WT
8	F	78	2	Absent/low	11q−	WT
9	M	51	0	Absent/low	Nor	WT
10	F	59	0	Absent/low	Nor	WT
11	M	69	2	Absent/low	13q−/17p−	WT
12	M	40	4	Interm/high	11q−	WT
13	M	74	2	Interm/high	13q−	WT
14	M	62	4	Interm/high	17p−	WT
15	M	62	0	Absent/low	11q−	WT
16	M	69	2	Absent/low	17p−	Mut (exon VII)
17	F	79	3	Absent/low	12+	WT
18	M	61	2	Interm/high	17p−	WT
19	M	63	4	Absent/low	13q−	WT
20	M	60	4	Absent/low	17p−	WT
21	M	59	2	Absent/low	13q−	WT
22	M	64	1	Interm/high	13q−	WT
23	M	57	1	Absent/low	12+	WT
24	M	67	4	ND	ND	WT
25	F	68	2	Interm/high	17p−	Mut (exon V)
26	F	55	0	Absent/low	ND	WT
27	M	61	2	Absent/low	17p−	Mut (exon VI)

Negative (−) indicates deletion; Mut, mutated; ND, not done; Nor, normal cytogenetics; and positive (+), trisomy.

ZAP-70 expression was determined by Western blot analysis.

FISH defects were found using a B-CLL FISH panel.