Histopathologic and immunohistochemical characterization of tumors
| Organ and tumor type . | Histology . | Immunohistochemistry . | Metastases . | Generation, sex, comment . |
|---|---|---|---|---|
| Mammary gland | ||||
| Adenocarcinoma | Solid, comedo, trabecular growth pattern, single acinar/ductal structures, necrosis, grade 3 | hVEGF-D positive in ductal part (surface); CD31, CD34, LYVE-1 negative in tumor cells | − | F1, male, left cervical mammary gland |
| Adenocarcinoma | Solid, comedo growth pattern, necrosis | hVEGF-D positive in ductal part; CK7 positive; CD31, CD34, LYVE-1 negative in tumor cells; increased number of vessels in tumor; angiogenic features | − | F3, female, left inguinal mammary gland, lactating, skin ulcerated |
| Mammary gland preserved at the edge, grade 3 | ||||
| Adenocarcinoma | Tubular, nestal, papillar, and trabecular growth pattern; necrosis | hVEGF-D positive in ductal part (surface); CK7 positive; CD31, CD34, LYVE-1 negative in tumor cells; increased number of vessels in tumor; angiogenic features | Lung metastases | F1, female, right inguinal mammary gland |
| Mammary gland preserved at the edge, grade 3 | ||||
| Adenocarcinoma | Tubular growth pattern, in situ component,mammary gland largely preserved, grade 1 | hVEGF-D positive in ductal part (surface); CD31, CD34, LYVE-1 negative in tumor cells; increased amount of vessels in tumor; angiogenic features | − | F1, female, right abdominal mammary gland |
| Lung | ||||
| Adenocarcinoma | Multifocal, foci of bronchioloalveolar proliferation, grade 1 | hVEGF-D negative | − | F1, female |
| Papillary adenocarcinoma | Multifocal, papillary growth pattern, grade 1 | hVEGF-D positive in stroma of papilla stalk; CD31, CD34, LYVE-1 negative in tumor cells | − | F1, male |
| Skin | ||||
| Basal cell carcinoma | Predominantly solid growth of round basal cells, necrosis | hVEGF-D negative; CD31, CD34, LYVE-1 negative in tumor cells | − | F3, female |
| Anaplastic carcinoma | Solid infiltrative growth of spindle and round cells, necrosis, infiltrating soft tissues (muscle, bone) | hVEGF-D positive in some tumor cells; CD31, CD34, LYVE-1 negative in tumor cells; increased amount of vessels in tumor; angiogenesis features | − | F1, male |
| Organ and tumor type . | Histology . | Immunohistochemistry . | Metastases . | Generation, sex, comment . |
|---|---|---|---|---|
| Mammary gland | ||||
| Adenocarcinoma | Solid, comedo, trabecular growth pattern, single acinar/ductal structures, necrosis, grade 3 | hVEGF-D positive in ductal part (surface); CD31, CD34, LYVE-1 negative in tumor cells | − | F1, male, left cervical mammary gland |
| Adenocarcinoma | Solid, comedo growth pattern, necrosis | hVEGF-D positive in ductal part; CK7 positive; CD31, CD34, LYVE-1 negative in tumor cells; increased number of vessels in tumor; angiogenic features | − | F3, female, left inguinal mammary gland, lactating, skin ulcerated |
| Mammary gland preserved at the edge, grade 3 | ||||
| Adenocarcinoma | Tubular, nestal, papillar, and trabecular growth pattern; necrosis | hVEGF-D positive in ductal part (surface); CK7 positive; CD31, CD34, LYVE-1 negative in tumor cells; increased number of vessels in tumor; angiogenic features | Lung metastases | F1, female, right inguinal mammary gland |
| Mammary gland preserved at the edge, grade 3 | ||||
| Adenocarcinoma | Tubular growth pattern, in situ component,mammary gland largely preserved, grade 1 | hVEGF-D positive in ductal part (surface); CD31, CD34, LYVE-1 negative in tumor cells; increased amount of vessels in tumor; angiogenic features | − | F1, female, right abdominal mammary gland |
| Lung | ||||
| Adenocarcinoma | Multifocal, foci of bronchioloalveolar proliferation, grade 1 | hVEGF-D negative | − | F1, female |
| Papillary adenocarcinoma | Multifocal, papillary growth pattern, grade 1 | hVEGF-D positive in stroma of papilla stalk; CD31, CD34, LYVE-1 negative in tumor cells | − | F1, male |
| Skin | ||||
| Basal cell carcinoma | Predominantly solid growth of round basal cells, necrosis | hVEGF-D negative; CD31, CD34, LYVE-1 negative in tumor cells | − | F3, female |
| Anaplastic carcinoma | Solid infiltrative growth of spindle and round cells, necrosis, infiltrating soft tissues (muscle, bone) | hVEGF-D positive in some tumor cells; CD31, CD34, LYVE-1 negative in tumor cells; increased amount of vessels in tumor; angiogenesis features | − | F1, male |