Table 1

Absolute numbers of distinct populations of CD4+ T cells from FVIII plasmid + anti-CD3– and FVIII plasmid only–treated mice at day 8, week 4, and week 6 after treatment

Treatment group/cell typeDay 8Week 4Week 6
FVIII plasmid only    
    CD4+ cells 10.8 (± 2.5) × 106 11.0 (± 1.8) × 106 11.4 (± 1.0) × 106 
    CD4+Foxp3+ cells 1.43 (± 0.20) × 106 1.32 (± 0.30) × 106 1.35 (± 0.30) × 106 
    CD4+CD25+Foxp3+ cells 1.1 (± 0.09) × 106 1.0 (± 0.24) × 106 1.2 (± 0.1) × 106 
    CD4+CD25−Foxp3+ cells 1.7 (± 0.37) × 105 1.9 (± 0.03) × 105 1.8 (± 0.23) × 105 
FVIII plasmid + anti-CD3    
    CD4+ cells 4.2 (± 1.1) × 106* 7.7 (± 0.8) × 106* 10.4 (± 1.5) × 106 
    CD4+Foxp3+ cells 1.28 (± 0.16) × 106 1.38 (± 0.13) × 106 1.4 (± 0.1) × 106 
    CD4+CD25+Foxp3+ cells 0.74 (± 0.17) × 106* 1.0 (± 0.1) × 106 1.1 (± 0.08) × 106 
    CD4+CD25−Foxp3+ cells 5.6 (± 1.0) × 105† 2.1 (± 0.02) × 105 1.9 (± 0.13) × 105 
Treatment group/cell typeDay 8Week 4Week 6
FVIII plasmid only    
    CD4+ cells 10.8 (± 2.5) × 106 11.0 (± 1.8) × 106 11.4 (± 1.0) × 106 
    CD4+Foxp3+ cells 1.43 (± 0.20) × 106 1.32 (± 0.30) × 106 1.35 (± 0.30) × 106 
    CD4+CD25+Foxp3+ cells 1.1 (± 0.09) × 106 1.0 (± 0.24) × 106 1.2 (± 0.1) × 106 
    CD4+CD25−Foxp3+ cells 1.7 (± 0.37) × 105 1.9 (± 0.03) × 105 1.8 (± 0.23) × 105 
FVIII plasmid + anti-CD3    
    CD4+ cells 4.2 (± 1.1) × 106* 7.7 (± 0.8) × 106* 10.4 (± 1.5) × 106 
    CD4+Foxp3+ cells 1.28 (± 0.16) × 106 1.38 (± 0.13) × 106 1.4 (± 0.1) × 106 
    CD4+CD25+Foxp3+ cells 0.74 (± 0.17) × 106* 1.0 (± 0.1) × 106 1.1 (± 0.08) × 106 
    CD4+CD25−Foxp3+ cells 5.6 (± 1.0) × 105† 2.1 (± 0.02) × 105 1.9 (± 0.13) × 105 
*

P < .05 compared with data of FVIII plasmid only.

†

P < .01 compared with data of FVIII plasmid only.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal