Table 3 Adoptive transfer of CD4 cells... | American Society of Hematology

Table 3

Adoptive transfer of CD4⁺ cells from tolerized mice at week 6 rendered partial dominant tolerance to sygeneic mice

CD4⁺ cell donors	hFVIII activity of receivers, percentage of normal			Anti-hFVIII antibodies of receivers, Bethesda units
CD4⁺ cell donors	Day 7	Day 14	Day 21	Day 7	Day 14	Day 21
Naive	317.0 ± 76.2	2.2 ± 2.3	0.5 ± 0.6	0	0	28.5 ± 5
FVIII plasmid only	28.1	0	0	1.5	55	97
FVIII plasmid + anti-CD3 (week 2)	331.1	12.5	0	0	5	20
FVIII plasmid + anti-CD3 (week 6)	262.5 ± 9.3	95.2 ± 46.4	40.0 ± 39.7	0	0	0

CD4⁺ cell donors	hFVIII activity of receivers, percentage of normal			Anti-hFVIII antibodies of receivers, Bethesda units
CD4⁺ cell donors	Day 7	Day 14	Day 21	Day 7	Day 14	Day 21
Naive	317.0 ± 76.2	2.2 ± 2.3	0.5 ± 0.6	0	0	28.5 ± 5
FVIII plasmid only	28.1	0	0	1.5	55	97
FVIII plasmid + anti-CD3 (week 2)	331.1	12.5	0	0	5	20
FVIII plasmid + anti-CD3 (week 6)	262.5 ± 9.3	95.2 ± 46.4	40.0 ± 39.7	0	0	0

Cells were isolated from donors 2 weeks or 6 weeks after plasmid injection.