Morphologic, immunohistochemical, genetic, and molecular characteristics of patients according to age groups
| . | 14 y or younger, n = 54 . | 15 to 18 y, n = 11 . | Older than 18 y, n = 182 . | P* . | |||
|---|---|---|---|---|---|---|---|
| no. . | % . | no. . | % . | no. . | % . | ||
| Morphology | |||||||
| Burkitt lymphoma | 16 | 30 | 1 | 9 | 7 | 4 | |
| Atypical Burkitt lymphoma | 10 | 19 | 1 | 9 | 13 | 7 | |
| DLBCL | 16 | 30 | 8 | 73 | 149 | 82 | |
| Follicular lymphoma III° | 2 | 4 | 1 | 9 | 1 | 1 | |
| B-NHL high grade | 10 | 19 | 0 | 0 | 12 | 7 | < .001 |
| CD10-IHC | |||||||
| Neg. | 8 | 15 | 7 | 70 | 106 | 62 | |
| Pos. | 44 | 85 | 3 | 30 | 66 | 38 | < .001 |
| BCL-2 IHC | |||||||
| Neg. | 33 | 65 | 4 | 40 | 40 | 23 | |
| Pos. | 18 | 35 | 6 | 60 | 137 | 77 | < .001 |
| BCL-6 IHC | |||||||
| Neg. | 3 | 6 | 2 | 18 | 32 | 20 | |
| Pos. | 45 | 94 | 9 | 82 | 132 | 80 | .028 |
| Ki67-index | |||||||
| Less than 95% | 25 | 46 | 7 | 64 | 143 | 81 | |
| 95% or more | 29 | 54 | 4 | 36 | 34 | 19 | < .001 |
| MYC-partner | |||||||
| IG-MYC | 38 | 70 | 3 | 27 | 33 | 19 | |
| Non-IG-MYC | 0 | 0 | 0 | 0 | 15 | 8 | |
| MYC-negative | 16 | 30 | 8 | 7 | 129 | 73 | < .001 |
| Cell of origin | |||||||
| ABC | 3 | 6 | 0 | 0 | 57 | 31 | |
| GCB | 47 | 87 | 8 | 73 | 86 | 47 | |
| Unclassified | 4 | 7 | 3 | 27 | 39 | 21 | < .001 |
| Molecular diagnosis | |||||||
| mBL | 34 | 63 | 2 | 18 | 20 | 11 | |
| Intermediate | 11 | 20 | 2 | 18 | 40 | 22 | |
| Non-mBL | 9 | 17 | 7 | 64 | 122 | 67 | < .001 |
| Major genetic groups | |||||||
| MYC-simple | 29 | 54 | 2 | 18 | 17 | 9 | |
| MYC-complex | 9 | 17 | 1 | 9 | 35 | 19 | |
| MYC-neg. | 16 | 30 | 8 | 73 | 129 | 71 | < .001 |
| . | 14 y or younger, n = 54 . | 15 to 18 y, n = 11 . | Older than 18 y, n = 182 . | P* . | |||
|---|---|---|---|---|---|---|---|
| no. . | % . | no. . | % . | no. . | % . | ||
| Morphology | |||||||
| Burkitt lymphoma | 16 | 30 | 1 | 9 | 7 | 4 | |
| Atypical Burkitt lymphoma | 10 | 19 | 1 | 9 | 13 | 7 | |
| DLBCL | 16 | 30 | 8 | 73 | 149 | 82 | |
| Follicular lymphoma III° | 2 | 4 | 1 | 9 | 1 | 1 | |
| B-NHL high grade | 10 | 19 | 0 | 0 | 12 | 7 | < .001 |
| CD10-IHC | |||||||
| Neg. | 8 | 15 | 7 | 70 | 106 | 62 | |
| Pos. | 44 | 85 | 3 | 30 | 66 | 38 | < .001 |
| BCL-2 IHC | |||||||
| Neg. | 33 | 65 | 4 | 40 | 40 | 23 | |
| Pos. | 18 | 35 | 6 | 60 | 137 | 77 | < .001 |
| BCL-6 IHC | |||||||
| Neg. | 3 | 6 | 2 | 18 | 32 | 20 | |
| Pos. | 45 | 94 | 9 | 82 | 132 | 80 | .028 |
| Ki67-index | |||||||
| Less than 95% | 25 | 46 | 7 | 64 | 143 | 81 | |
| 95% or more | 29 | 54 | 4 | 36 | 34 | 19 | < .001 |
| MYC-partner | |||||||
| IG-MYC | 38 | 70 | 3 | 27 | 33 | 19 | |
| Non-IG-MYC | 0 | 0 | 0 | 0 | 15 | 8 | |
| MYC-negative | 16 | 30 | 8 | 7 | 129 | 73 | < .001 |
| Cell of origin | |||||||
| ABC | 3 | 6 | 0 | 0 | 57 | 31 | |
| GCB | 47 | 87 | 8 | 73 | 86 | 47 | |
| Unclassified | 4 | 7 | 3 | 27 | 39 | 21 | < .001 |
| Molecular diagnosis | |||||||
| mBL | 34 | 63 | 2 | 18 | 20 | 11 | |
| Intermediate | 11 | 20 | 2 | 18 | 40 | 22 | |
| Non-mBL | 9 | 17 | 7 | 64 | 122 | 67 | < .001 |
| Major genetic groups | |||||||
| MYC-simple | 29 | 54 | 2 | 18 | 17 | 9 | |
| MYC-complex | 9 | 17 | 1 | 9 | 35 | 19 | |
| MYC-neg. | 16 | 30 | 8 | 73 | 129 | 71 | < .001 |
Percentages were calculated on the basis of the number of cases that could be evaluated; data were not available for all cases. Percentages may not total 100 because of rounding.
IHC indicates immunohistochemistry.
P values were calculated with the use of Fisher exact test or the chi-square test and refer to differences between the cases 14 years or younger and older than 18 years. The group of patients 15 to 18 years were not included in the analysis and are displayed for completeness only.