D-d time course from T90 to T390 and recurrences observed in the two months between each D-d measurement
| Time points . | Patients, N (D-d not one) . | D-d . | D-d normal also at previous T . | D-d newly abnormal . | D-d abnormal also at previous T . | D-d normal but altered at previous T . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal (%) . | Abnormal (%) . | No. of patients . | rVTE (%) . | No. of patients (%) . | rVTE (%) . | No. of patients . | rVTE (%) . | No. of patients . | rVTE (%) . | ||
| T90 | 228 (3) | 194 | 4 (2.1) | 31 (13.8) | 3 (9.7)* | ||||||
| 3 DVTs, 1 PE | 2 DVTs, 1 PE | ||||||||||
| 2 patients resumed | 2 patients withdrew | ||||||||||
| VKAs for SVT | |||||||||||
| T150 | 209 (1) | 174 | 34 (16.3) | 162 | 0 (0) | 22 (10.6) | 1 (4.5)† | 12 | 0 | 12 | 1 (8.3)‡ |
| 2 patients withdrew | 1 DVT | 1 DVT | |||||||||
| T210 | 193 | 144 | 49 (25.3) | 132 | 0 (0) | 30 (15.5) | 1 (3.3)§ | 19 | 2 (10.5)∥ | 12 | 0 |
| 1 DVT | 2 DVTs | ||||||||||
| T270 | 178 (1) | 130 | 47 (26.5) | 115 | 0 (0) | 19 (10.7) | 0 | 28 | 3 | 15 | 0 |
| 1 patient resumed | (10.7)¶ | ||||||||||
| VKAs for afib | 3 DVTs | ||||||||||
| T330 | 163 (4) | 114 | 45 (28.3) | 97 | 1 (1) | 20 (12.5) | 0 | 25 | 0 | 17 | 0 |
| 1 DVT | |||||||||||
| T390 | 144 (9) | 100 | 35 (26) | 84 | 0 (0) | 11 (8.1) | 0 | 24 | 0 | 16 | 0 |
| Time points . | Patients, N (D-d not one) . | D-d . | D-d normal also at previous T . | D-d newly abnormal . | D-d abnormal also at previous T . | D-d normal but altered at previous T . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal (%) . | Abnormal (%) . | No. of patients . | rVTE (%) . | No. of patients (%) . | rVTE (%) . | No. of patients . | rVTE (%) . | No. of patients . | rVTE (%) . | ||
| T90 | 228 (3) | 194 | 4 (2.1) | 31 (13.8) | 3 (9.7)* | ||||||
| 3 DVTs, 1 PE | 2 DVTs, 1 PE | ||||||||||
| 2 patients resumed | 2 patients withdrew | ||||||||||
| VKAs for SVT | |||||||||||
| T150 | 209 (1) | 174 | 34 (16.3) | 162 | 0 (0) | 22 (10.6) | 1 (4.5)† | 12 | 0 | 12 | 1 (8.3)‡ |
| 2 patients withdrew | 1 DVT | 1 DVT | |||||||||
| T210 | 193 | 144 | 49 (25.3) | 132 | 0 (0) | 30 (15.5) | 1 (3.3)§ | 19 | 2 (10.5)∥ | 12 | 0 |
| 1 DVT | 2 DVTs | ||||||||||
| T270 | 178 (1) | 130 | 47 (26.5) | 115 | 0 (0) | 19 (10.7) | 0 | 28 | 3 | 15 | 0 |
| 1 patient resumed | (10.7)¶ | ||||||||||
| VKAs for afib | 3 DVTs | ||||||||||
| T330 | 163 (4) | 114 | 45 (28.3) | 97 | 1 (1) | 20 (12.5) | 0 | 25 | 0 | 17 | 0 |
| 1 DVT | |||||||||||
| T390 | 144 (9) | 100 | 35 (26) | 84 | 0 (0) | 11 (8.1) | 0 | 24 | 0 | 16 | 0 |
rVTE indicates recurrent venous thromboembolism; SVT, superficial vein thrombosis; and afib, atrial fibrillation.
P = .05 vs D-d normal also previously.
P = .11 vs D-d normal also previously.
P = .07 vs D-d normal also previously.
P = .18 vs D-d normal also previously.
P = .015 vs D-d normal also previously.
P = .007 vs D-d normal also previously.