Table 4

Enrichment of BCL6-related gene expression signatures and direct targets in DS-ALL profile genes (FDR < 15%)

SizePQ-value
Oncomine “Molecular Concepts” enriched in DS-ALL up-regulated genes    
    EREB lymphoblastoid cell line BCL6 transfection top 10% overexpressed30  17 .004 0.093 
    Ramos Burkitt lymphoma cell line BCL6 pest mutant top 5% underexpressed in anti-IgM30  11 .011 0.138 
    Lymphoma BCL6 break top 5% overexpressed31  11 .019 0.138 
    Lymphoma BCL6 break top 10% overexpressed31  17 .022 0.138 
    BCL6 direct targets32  11 .030 0.147 
Oncomine “Molecular Concepts” enriched in DS-ALL down-regulated genes    
    Lymphoma BCL6 break top 10% underexpressed31  36 < .001 0.001 
    EREB lymphoblastoid cell line BCL6 transfection top 10% underexpressed30  26 < .001 0.001 
    Lymphoma BCL6 break top 5% underexpressed31  20 .001 0.008 
SizePQ-value
Oncomine “Molecular Concepts” enriched in DS-ALL up-regulated genes    
    EREB lymphoblastoid cell line BCL6 transfection top 10% overexpressed30  17 .004 0.093 
    Ramos Burkitt lymphoma cell line BCL6 pest mutant top 5% underexpressed in anti-IgM30  11 .011 0.138 
    Lymphoma BCL6 break top 5% overexpressed31  11 .019 0.138 
    Lymphoma BCL6 break top 10% overexpressed31  17 .022 0.138 
    BCL6 direct targets32  11 .030 0.147 
Oncomine “Molecular Concepts” enriched in DS-ALL down-regulated genes    
    Lymphoma BCL6 break top 10% underexpressed31  36 < .001 0.001 
    EREB lymphoblastoid cell line BCL6 transfection top 10% underexpressed30  26 < .001 0.001 
    Lymphoma BCL6 break top 5% underexpressed31  20 .001 0.008 
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