Arf-Mdm2-p53 protein expression in Slp65-deficient leukemias
| Tumor . | p53 . | p19ARF . | Mdm2 . |
|---|---|---|---|
| Aberrant p53 | |||
| S13 | High* | High | Expressed |
| S92 | Expressed | Low | Expressed |
| S96 | Expressed | Expressed | Expressed |
| S100 | Low | High | Expressed |
| S102 | Low | High | Expressed |
| S116 | Low | High | Expressed |
| S203 | Low | High | Expressed |
| S208 | Low | High | Expressed |
| p53 wild-type, Arf expressed/ high | |||
| S14 | Undetected | High | Expressed |
| S25 | Undetected | High | Expressed |
| S75 | Undetected | High | Undetected |
| S99 | Undetected | High | Expressed |
| S101 | Undetected | High | Expressed |
| S107 | Undetected | High | Expressed |
| S109 | Undetected | High | Expressed |
| S114 | Undetected | High | Expressed |
| BS27 | Undetected | High | Expressed |
| BS29 | Undetected | High | Expressed |
| BS30 | Undetected | Expressed | Expressed |
| BS36 | Undetected | High | Low |
| BS45 | Undetected | High | Low |
| BS50 | Undetected | High | Low |
| BS53 | Undetected | High | Expressed |
| BS70 | Undetected | High | Expressed |
| BS91 | Undetected | High | Expressed |
| BS103 | Undetected | High | Expressed |
| BS105 | Undetected | High | Expressed |
| BS108 | Undetected | High | Expressed |
| BS115 | Undetected | High | Expressed |
| BS118 | Undetected | High | Low |
| BS119 | Undetected | High | Expressed |
| BS123 | Undetected | High | Expressed |
| BS124 | Undetected | High | Expressed |
| BS301 | Undetected | High | Expressed |
| BS303 | Undetected | High | Expressed |
| BS304 | Undetected | High | Expressed |
| BS305 | Undetected | High | Expressed |
| BS306 | Undetected | High | Expressed |
| BS309 | Undetected | High | Expressed |
| BS310 | Undetected | High | Expressed |
| BS311 | Undetected | Expressed | Expressed |
| BS312 | Undetected | Expressed | Expressed |
| BS316 | Undetected | High | Expressed |
| BS318 | Undetected | Expressed | Expressed |
| BS326 | Undetected | High | Expressed |
| BS327 | Undetected | High | Expressed |
| Arf low/ undetected | |||
| S98 | Undetected | Low | Expressed |
| BS72 | Undetected | Undetected | Low |
| BS93 | Undetected | Undetected | Expressed |
| p53-deficient tumors, Arf expressed | |||
| PS15 | Undetected | High | Expressed |
| PS16 | Undetected | High | Expressed |
| PS18 | Undetected | High | Expressed |
| PS19 | Undetected | Expressed | Expressed |
| PS21 | Undetected | High | Expressed |
| PS23 | Undetected | High | Expressed |
| PS24 | Undetected | High | Expressed |
| p53-deficient tumors, Arf undetected | |||
| PS17 | Undetected | Undetected | Expressed |
| PS22 | Undetected | Undetected | Low |
| PS27 | Undetected | Undetected | Expressed |
| Tumor . | p53 . | p19ARF . | Mdm2 . |
|---|---|---|---|
| Aberrant p53 | |||
| S13 | High* | High | Expressed |
| S92 | Expressed | Low | Expressed |
| S96 | Expressed | Expressed | Expressed |
| S100 | Low | High | Expressed |
| S102 | Low | High | Expressed |
| S116 | Low | High | Expressed |
| S203 | Low | High | Expressed |
| S208 | Low | High | Expressed |
| p53 wild-type, Arf expressed/ high | |||
| S14 | Undetected | High | Expressed |
| S25 | Undetected | High | Expressed |
| S75 | Undetected | High | Undetected |
| S99 | Undetected | High | Expressed |
| S101 | Undetected | High | Expressed |
| S107 | Undetected | High | Expressed |
| S109 | Undetected | High | Expressed |
| S114 | Undetected | High | Expressed |
| BS27 | Undetected | High | Expressed |
| BS29 | Undetected | High | Expressed |
| BS30 | Undetected | Expressed | Expressed |
| BS36 | Undetected | High | Low |
| BS45 | Undetected | High | Low |
| BS50 | Undetected | High | Low |
| BS53 | Undetected | High | Expressed |
| BS70 | Undetected | High | Expressed |
| BS91 | Undetected | High | Expressed |
| BS103 | Undetected | High | Expressed |
| BS105 | Undetected | High | Expressed |
| BS108 | Undetected | High | Expressed |
| BS115 | Undetected | High | Expressed |
| BS118 | Undetected | High | Low |
| BS119 | Undetected | High | Expressed |
| BS123 | Undetected | High | Expressed |
| BS124 | Undetected | High | Expressed |
| BS301 | Undetected | High | Expressed |
| BS303 | Undetected | High | Expressed |
| BS304 | Undetected | High | Expressed |
| BS305 | Undetected | High | Expressed |
| BS306 | Undetected | High | Expressed |
| BS309 | Undetected | High | Expressed |
| BS310 | Undetected | High | Expressed |
| BS311 | Undetected | Expressed | Expressed |
| BS312 | Undetected | Expressed | Expressed |
| BS316 | Undetected | High | Expressed |
| BS318 | Undetected | Expressed | Expressed |
| BS326 | Undetected | High | Expressed |
| BS327 | Undetected | High | Expressed |
| Arf low/ undetected | |||
| S98 | Undetected | Low | Expressed |
| BS72 | Undetected | Undetected | Low |
| BS93 | Undetected | Undetected | Expressed |
| p53-deficient tumors, Arf expressed | |||
| PS15 | Undetected | High | Expressed |
| PS16 | Undetected | High | Expressed |
| PS18 | Undetected | High | Expressed |
| PS19 | Undetected | Expressed | Expressed |
| PS21 | Undetected | High | Expressed |
| PS23 | Undetected | High | Expressed |
| PS24 | Undetected | High | Expressed |
| p53-deficient tumors, Arf undetected | |||
| PS17 | Undetected | Undetected | Expressed |
| PS22 | Undetected | Undetected | Low |
| PS27 | Undetected | Undetected | Expressed |
Immunoblotting experiments were performed twice, and a summary of those experiments is shown.