Table 3 In vivo function of MC... | American Society of Hematology

Table 3

In vivo function of MC proteases, based on MC protease-deficient mouse strains

MC protease deficiency	Phenotype	Implicated mechanism	Reference
mMCP-4	Less severe collagen induced arthritis	Effects on anticollagen II IgG generation, inflammation	35
	Less development of AAAs	Effects on inflammation, apoptosis, elastin degradation	36
	Increased susceptibility to allergic airway inflammation	Effects on smooth muscle cells, inflammation	37
	Tissue accumulation of ECM	Defective fibronectin and proMMP-9 processing	38,39
	Reduced basal intestinal permeability	Effects on epithelial cell migration	40
mMCP-5	Decreased ischemia reperfusion injury	Unknown	41
mMCP-1	Increased susceptibility to T spiralis infection	Promotion of capillary permeability; degradation of cell-cell junctions	42,–44
mMCP-6	Less severe passively induced arthritis (K/BxN model)	Effect on expression of the neutrophil chemotactic factors CXCL1/KC, CXCL5/LIX, and CXCL8/IL-8; effect on aggrecan degradation	34
	Nonadequate response to T spiralis infection	Effect on eosinophil recruitment	24
	Increased susceptibility to K pneumoniae infection	Effect on neutrophil recruitment and production of inflammatory cytokines	25
	Less severe passively induced arthritis (methyl-BSA/IL-1β model)	Unknown	33
mMCP-7*	Less severe passively induced arthritis (methyl-BSA/IL-1β model)	Unknown	33
MC-CPA	Increased susceptibility to snake poison envenomation	Degradation of sarafotoxins	45,46 †
	Defective granule staining	Effects on serglycin proteoglycan solubility	47

MC protease deficiency	Phenotype	Implicated mechanism	Reference
mMCP-4	Less severe collagen induced arthritis	Effects on anticollagen II IgG generation, inflammation	35
	Less development of AAAs	Effects on inflammation, apoptosis, elastin degradation	36
	Increased susceptibility to allergic airway inflammation	Effects on smooth muscle cells, inflammation	37
	Tissue accumulation of ECM	Defective fibronectin and proMMP-9 processing	38,39
	Reduced basal intestinal permeability	Effects on epithelial cell migration	40
mMCP-5	Decreased ischemia reperfusion injury	Unknown	41
mMCP-1	Increased susceptibility to T spiralis infection	Promotion of capillary permeability; degradation of cell-cell junctions	42,–44
mMCP-6	Less severe passively induced arthritis (K/BxN model)	Effect on expression of the neutrophil chemotactic factors CXCL1/KC, CXCL5/LIX, and CXCL8/IL-8; effect on aggrecan degradation	34
	Nonadequate response to T spiralis infection	Effect on eosinophil recruitment	24
	Increased susceptibility to K pneumoniae infection	Effect on neutrophil recruitment and production of inflammatory cytokines	25
	Less severe passively induced arthritis (methyl-BSA/IL-1β model)	Unknown	33
mMCP-7*	Less severe passively induced arthritis (methyl-BSA/IL-1β model)	Unknown	33
MC-CPA	Increased susceptibility to snake poison envenomation	Degradation of sarafotoxins	45,46 †
	Defective granule staining	Effects on serglycin proteoglycan solubility	47

MC indicates mast cell; mMCP, mouse mast cell protease; CPA, carboxypeptidase A; AAA, abdominal aortic aneurysm; ECM, extracellular matrix; and proMMP, pro-matrix metalloprotease.

Refers to the spontaneous mMCP-7-deficiency of C57BL/6 mice.²⁶

†

Data obtained by shRNA-based technology.

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