Table 3 Immunologic characteristics of... | American Society of Hematology

Table 3

Immunologic characteristics of somatic ALPS patients

Patient	Original ALPS classification	IgG*	Lymphocyte*	% DNT†	% CD3*	% CD4*	% CD8*	% CD20*	% CD56⁺CD3⁻*
43	Phenotype	1500	1.15	5.2	55.6	22.6	29.1	26.4	13.5
84	Phenotype	650	2.73	7.1	90.3	58.8	22.7	7.4	2.2
135	Phenotype	2060	0.87	4.8	64.6	16.5	46.7	12.5	22.9
228	Phenotype	2460	6.53	17.2	63.2	17.6	23.5	35.0	1.8
235	Phenotype	2520	2.00	10.6	43.7	14.6	28.7	8.6	47.7
241	Phenotype	3110	1.40	18.6	83.5	32.7	31.7	10.1	6.4
	Mean ± SE	2050 ± 354	2.4 ± 0.9	10.6 ± 2.5	66.8 ± 7.1	27.1 ± 6.9	30.4 ± 3.6	16.7 ± 4.6	15.8 ± 7.2
108	Type III	3800	0.81	3.5	84.6	38.3	36.8	6.0	9.4
164	Type III	1230	1.55	4.8	73.3	34.2	29.4	20.3	6.4
256	Type III	1680	2.11	3.9	83.0	35.3	42.3	3.5	13.5
262	Type III	2020	1.23	8.1	74.2	38.9	27.2	16.6	9.2
263	Type III	1690	2.10	2.7	66.3	34.5	29.9	22.6	11.1
276	Type III	1840	1.20	4.0	81.1	37.6	29.3	14.6	3.9
	Mean ± SE	2043 ± 367	1.5 ± 0.2	4.5 ± 0.8‡	77.1 ± 2.9	36.5 ± 0.8	32.5 ± 2.4	13.9 ± 3.1	8.9 ± 1.4

Patient	Original ALPS classification	IgG*	Lymphocyte*	% DNT†	% CD3*	% CD4*	% CD8*	% CD20*	% CD56⁺CD3⁻*
43	Phenotype	1500	1.15	5.2	55.6	22.6	29.1	26.4	13.5
84	Phenotype	650	2.73	7.1	90.3	58.8	22.7	7.4	2.2
135	Phenotype	2060	0.87	4.8	64.6	16.5	46.7	12.5	22.9
228	Phenotype	2460	6.53	17.2	63.2	17.6	23.5	35.0	1.8
235	Phenotype	2520	2.00	10.6	43.7	14.6	28.7	8.6	47.7
241	Phenotype	3110	1.40	18.6	83.5	32.7	31.7	10.1	6.4
	Mean ± SE	2050 ± 354	2.4 ± 0.9	10.6 ± 2.5	66.8 ± 7.1	27.1 ± 6.9	30.4 ± 3.6	16.7 ± 4.6	15.8 ± 7.2
108	Type III	3800	0.81	3.5	84.6	38.3	36.8	6.0	9.4
164	Type III	1230	1.55	4.8	73.3	34.2	29.4	20.3	6.4
256	Type III	1680	2.11	3.9	83.0	35.3	42.3	3.5	13.5
262	Type III	2020	1.23	8.1	74.2	38.9	27.2	16.6	9.2
263	Type III	1690	2.10	2.7	66.3	34.5	29.9	22.6	11.1
276	Type III	1840	1.20	4.0	81.1	37.6	29.3	14.6	3.9
	Mean ± SE	2043 ± 367	1.5 ± 0.2	4.5 ± 0.8‡	77.1 ± 2.9	36.5 ± 0.8	32.5 ± 2.4	13.9 ± 3.1	8.9 ± 1.4

Normal ranges as published by Comans-Bitter, et al²⁹ and Mayo Clinic pediatric reference values.³⁰

Percent DNT normal values < 1.5% of total lymphocytes.

Value of P < .05.