Table 6 Multivariate analysis (Cox... | American Society of Hematology

Table 6

Multivariate analysis (Cox regression) on the RFS and OS

Variable	RFS			OS
Variable	RR	95% CI	P	RR	95% CI	P
Whole cohort (n = 330)
Age†	1.334	0.929-1.915	.119	2.724	1.902-3.902	< .001*
WBC‡	1.377	0.941-2.014	.100	1.863	1.297-2.677	.001*
Karyotype§	1.851	1.017-3.368	.044*	2.684	1.626-4.432	< .001*
NPM1/FLT3-ITD‖	0.400	0.208-0.770	.006*	0.344	0.165-0.714	.004*
CEBPA¶	0.516	0.300-0.889	.017*	0.371	0.187-0.737	.005*
WT1	2.601	1.562-4.333	< .001*	2.141	1.188-3.859	.011*
Patients with normal karyotype and age < 60 y (n = 121)
Age†	2.340	1.114-4.787	.020*	2.515	1.065-5.939	.035*
WBC‡	2.533	1.231-5.210	.012*	5.508	2.536-11.964	< .001*
NPM1/FLT3-ITD‖	0.151	0.059-0.387	< .001*	0.246	0.079-0.768	.016*
CEBPA¶	0.170	0.070-0.416	< .001*	0.146	0.045-0.475	.001*
WT1	3.806	1.588-9.122	.003*	3.752	1.195-11.783	.024*

Variable	RFS			OS
Variable	RR	95% CI	P	RR	95% CI	P
Whole cohort (n = 330)
Age†	1.334	0.929-1.915	.119	2.724	1.902-3.902	< .001*
WBC‡	1.377	0.941-2.014	.100	1.863	1.297-2.677	.001*
Karyotype§	1.851	1.017-3.368	.044*	2.684	1.626-4.432	< .001*
NPM1/FLT3-ITD‖	0.400	0.208-0.770	.006*	0.344	0.165-0.714	.004*
CEBPA¶	0.516	0.300-0.889	.017*	0.371	0.187-0.737	.005*
WT1	2.601	1.562-4.333	< .001*	2.141	1.188-3.859	.011*
Patients with normal karyotype and age < 60 y (n = 121)
Age†	2.340	1.114-4.787	.020*	2.515	1.065-5.939	.035*
WBC‡	2.533	1.231-5.210	.012*	5.508	2.536-11.964	< .001*
NPM1/FLT3-ITD‖	0.151	0.059-0.387	< .001*	0.246	0.079-0.768	.016*
CEBPA¶	0.170	0.070-0.416	< .001*	0.146	0.045-0.475	.001*
WT1	3.806	1.588-9.122	.003*	3.752	1.195-11.783	.024*

RR indicates relative risk; and CI, confidence interval.

Statistically significant (P < .05).

Age more than 50 years relative to age less than or equal to 50 years (the reference).

WBC greater than 50 000/μL versus less than 50 000/μL.

Unfavorable cytogenetics versus others.

NPM1^mut/FLT3-ITD⁻ versus other subtypes.

CEBPA^{double-mutation} versus others.