Antigen expression on cell lines of B-cell malignancies
| Malignancy/cell line . | Labetuzumab (isotype control) . | IMMU-114 (HLA-DR) . | Milatuzumab (CD74) . | Epratuzumab (CD22) . | Veltuzumab (CD20) . |
|---|---|---|---|---|---|
| AML | |||||
| GDM-1 | 4.4 | 553.5 | 35.9 | 7.2 | 4.3 |
| Kasumi-1 | 6.6 | 8.9 | 9.5 | 8.5 | 7.5 |
| Kasumi-3 | 6.0 | 444.9 | 17.5 | 5.8 | 4.9 |
| MCL | |||||
| Jeko-1 | 5.6 | 539.0 | 29.0 | 5.8 | 250.1 |
| Granta-519 | 4.2 | 1797.2 | 41.4 | 21.6 | 805.4 |
| ALL | |||||
| RS4;11 | 3.3 | 252.2 | 35.2 | 59.5 | 3.0 |
| REH | 3.0 | 2583.1 | 70.6 | 50.8 | 15.0 |
| 697 | 4.0 | 1108.4 | 49.5 | 52.2 | 13.1 |
| MN60 | 8.4 | 2522.1 | 57.0 | 44.1 | 719.4 |
| HCL | |||||
| HC-1 | 8.1 | 5501.2 | 164.0 | 73.9 | 1079.4 |
| CLL | |||||
| MEC-1 | 5.4 | 2421.5 | 41.4 | 35.5 | 270.5 |
| WAC | 5.2 | 798.8 | 17.4 | 14.2 | 210.6 |
| NHL | |||||
| Daudi | 8.0 | 2092.5 | 49.8 | 130.2 | 499.8 |
| Namalwa | 5.4 | 554.5 | 24.9 | 17.4 | 24.9 |
| Raji | 6.2 | 2316.8 | 130.6 | 54.6 | 391.3 |
| Ramos | 3.8 | 373.3 | 45.2 | 38.7 | 516.0 |
| RL | 6.2 | 1663.6 | 56.0 | 34.2 | 264.5 |
| SU-DHL-6 | 3.3 | 1186.7 | 73.4 | 28.1 | 1466.4 |
| WSU-FSCCL | 5.3 | 2030.2 | 20.9 | 14.1 | 36.6 |
| MM | |||||
| CAG | 4.1 | 2803.9 | 86.9 | 4.1 | 4.1 |
| KMS-11 | 2.8 | 615.8 | 16.5 | 3.2 | 3.4 |
| KMS12-BM | 5.2 | 1501.8 | 17.9 | 10.5 | 318.0 |
| KMS12-PE | 3.1 | 939.7 | 16.3 | 3.2 | 3.0 |
| OPM-2 | 4.2 | 3.4 | 3.4 | 3.2 | 3.3 |
| Malignancy/cell line . | Labetuzumab (isotype control) . | IMMU-114 (HLA-DR) . | Milatuzumab (CD74) . | Epratuzumab (CD22) . | Veltuzumab (CD20) . |
|---|---|---|---|---|---|
| AML | |||||
| GDM-1 | 4.4 | 553.5 | 35.9 | 7.2 | 4.3 |
| Kasumi-1 | 6.6 | 8.9 | 9.5 | 8.5 | 7.5 |
| Kasumi-3 | 6.0 | 444.9 | 17.5 | 5.8 | 4.9 |
| MCL | |||||
| Jeko-1 | 5.6 | 539.0 | 29.0 | 5.8 | 250.1 |
| Granta-519 | 4.2 | 1797.2 | 41.4 | 21.6 | 805.4 |
| ALL | |||||
| RS4;11 | 3.3 | 252.2 | 35.2 | 59.5 | 3.0 |
| REH | 3.0 | 2583.1 | 70.6 | 50.8 | 15.0 |
| 697 | 4.0 | 1108.4 | 49.5 | 52.2 | 13.1 |
| MN60 | 8.4 | 2522.1 | 57.0 | 44.1 | 719.4 |
| HCL | |||||
| HC-1 | 8.1 | 5501.2 | 164.0 | 73.9 | 1079.4 |
| CLL | |||||
| MEC-1 | 5.4 | 2421.5 | 41.4 | 35.5 | 270.5 |
| WAC | 5.2 | 798.8 | 17.4 | 14.2 | 210.6 |
| NHL | |||||
| Daudi | 8.0 | 2092.5 | 49.8 | 130.2 | 499.8 |
| Namalwa | 5.4 | 554.5 | 24.9 | 17.4 | 24.9 |
| Raji | 6.2 | 2316.8 | 130.6 | 54.6 | 391.3 |
| Ramos | 3.8 | 373.3 | 45.2 | 38.7 | 516.0 |
| RL | 6.2 | 1663.6 | 56.0 | 34.2 | 264.5 |
| SU-DHL-6 | 3.3 | 1186.7 | 73.4 | 28.1 | 1466.4 |
| WSU-FSCCL | 5.3 | 2030.2 | 20.9 | 14.1 | 36.6 |
| MM | |||||
| CAG | 4.1 | 2803.9 | 86.9 | 4.1 | 4.1 |
| KMS-11 | 2.8 | 615.8 | 16.5 | 3.2 | 3.4 |
| KMS12-BM | 5.2 | 1501.8 | 17.9 | 10.5 | 318.0 |
| KMS12-PE | 3.1 | 939.7 | 16.3 | 3.2 | 3.0 |
| OPM-2 | 4.2 | 3.4 | 3.4 | 3.2 | 3.3 |
Values are mean fluorescence intensities.