Patient characteristics and clinical features of neurolymphomatosis
| Characteristic . | Group A: literature review with MGH case series (1972-2000), N = 72 . | Group B: literature review, case reports (2001-2008), N = 44 . | Group C: current IPCG case series (1993-2008), N = 50 . |
|---|---|---|---|
| Sex | |||
| Male | 39 (54) | 26 (59) | 30 (60) |
| Female | 33 (46) | 16 (36) | 20 (40) |
| Not reported | 2 (4.5) | ||
| Median age, y (range) | 63 (18-84) | 56 (16-71) | 55.5 (18-80) |
| NL as an extranodal site of systemic lymphoma | 29 (40) | 27 (61) | 33 (66) |
| NL as the presentation of malignancy | NA | 13 (29.5) | 13 (26) |
| Malignant cell type | |||
| B cells | 59 (82) | 29 (66) | 41 (82) |
| T cells | 4 (5) | 11 (25) | 5 (10) |
| NK cells | 1 (2) | ||
| Not classified | 9 (13) | 3 (6.8) | 4 (8) |
| Parenchymal brain involvement | 19 (26) | NA | 11 (22), PCNSL |
| Affected neural structures* | |||
| Peripheral nerves | 46 (64) | 9 (20) | 30 (60) |
| Spinal nerves | 47 (65) | 14 (32) | 24 (48) |
| Neural plexus | 23 (32) | 15 (34) | 20 (40) |
| Cranial nerves | 37 (51) | 15 (34) | 23 (46) |
| Painful neuropathy | 34 (47) | 25 (57) | 38 (76) |
| Type of neuropathy | |||
| Pure motor | NA | 7 (16) | 11 (22) |
| Pure sensory | NA | 8 (18) | 1 (2) |
| Sensorimotor | NA | 23 (52) | 36 (72) |
| Not reported | 6 (14) | 2 (4) |
| Characteristic . | Group A: literature review with MGH case series (1972-2000), N = 72 . | Group B: literature review, case reports (2001-2008), N = 44 . | Group C: current IPCG case series (1993-2008), N = 50 . |
|---|---|---|---|
| Sex | |||
| Male | 39 (54) | 26 (59) | 30 (60) |
| Female | 33 (46) | 16 (36) | 20 (40) |
| Not reported | 2 (4.5) | ||
| Median age, y (range) | 63 (18-84) | 56 (16-71) | 55.5 (18-80) |
| NL as an extranodal site of systemic lymphoma | 29 (40) | 27 (61) | 33 (66) |
| NL as the presentation of malignancy | NA | 13 (29.5) | 13 (26) |
| Malignant cell type | |||
| B cells | 59 (82) | 29 (66) | 41 (82) |
| T cells | 4 (5) | 11 (25) | 5 (10) |
| NK cells | 1 (2) | ||
| Not classified | 9 (13) | 3 (6.8) | 4 (8) |
| Parenchymal brain involvement | 19 (26) | NA | 11 (22), PCNSL |
| Affected neural structures* | |||
| Peripheral nerves | 46 (64) | 9 (20) | 30 (60) |
| Spinal nerves | 47 (65) | 14 (32) | 24 (48) |
| Neural plexus | 23 (32) | 15 (34) | 20 (40) |
| Cranial nerves | 37 (51) | 15 (34) | 23 (46) |
| Painful neuropathy | 34 (47) | 25 (57) | 38 (76) |
| Type of neuropathy | |||
| Pure motor | NA | 7 (16) | 11 (22) |
| Pure sensory | NA | 8 (18) | 1 (2) |
| Sensorimotor | NA | 23 (52) | 36 (72) |
| Not reported | 6 (14) | 2 (4) |
Values are no. (%), except for age (y). Group A consists of a retrospective case series of 25 patients diagnosed in Massachusetts General Hospital (MGH) and literature review of additional 47 cases that were published together.1 Group B is based on literature review.4,7-41 Group C is the current case series.
NA indicates not available; and PCNSL, primary central nervous system lymphoma.
Involvement of multiple sites was common.