Baseline characteristics and relationship between immunoglobulin light-chain type/levels and organ involvement
| Variable . | All patients . | Light-chain type . | dFLC . | ||||
|---|---|---|---|---|---|---|---|
| κ-restricted patients . | λ-restricted patients . | P . | High (> 19.6 mg/dL) . | Low (≤ 19.6 mg/dL) . | P . | ||
| Median κ FLC, mg/dL (range) | 1.6 (0.032-1360) | 31.4 (0.3-1360) | 1.2 (0.032-13) | NA | |||
| Median λ FLC, mg/dL (range) | 11.4 (0.06-2480) | 1.3 (0.06-24) | 19.4 (0.9-2480) | NA | |||
| κ:λ ratio abnormal, n (%) | 644 (88) | 191 (95) | 453 (86) | < .001 | |||
| Median dFLC, mg/dL (range) | 19.6 (0.01-2478) | 29.4 (0.01-1359) | 18.2 (0.03-2478) | < .001 | 56.2 (19.8-2478) | 7.8 (0.01-19.6) | NA |
| Median plasma cell % (range) | 8 (0-95) | 9.5 (1-95) | 8 (0-90) | .04 | 10 (2-95) | 6 (0-60) | < .001 |
| Heart, n (%) | 445 (65) | 109 (60) | 331 (67) | NS | 244 (71) | 196 (59) | < .001 |
| Septum > 12 mm | 423 (63) | 104 (58) | 316 (65) | .09 | 233 (69) | 187 (57) | .001 |
| EF < 50% | 151 (23) | 34 (19) | 117 (23) | NS | 100 (30) | 51 (16) | < .001 |
| cTnT > 0.035 ng/mL | 265 (44) | 60 (38) | 205 (47) | .05 | 154 (53) | 111 (36) | < .001 |
| NT-ProBNP > 332 pg/mL | 345 (70) | 96 (71) | 249 (70) | NS | 244 (71) | 196 (59) | < .001 |
| Liver, n (%) | 129 (20) | 57 (31) | 72 (16) | < .0001 | 65 (20) | 64 (20) | NS |
| Bilirubin > 1.5 mg/dL | 63 (10) | 23 (13) | 40 (9) | NS | 40 (12.5) | 23 (7) | .03 |
| Alk Phos > 1.5 × ULN | 118 (18) | 51 (28) | 67 (14) | .0002 | 59 (18) | 59 (18) | NS |
| Median serum carotene (range) | 126 (12-662) | 113 (12-370) | 130 (23-662) | .0006 | 107 (12-363) | 141 (36-662) | < .001 |
| Kidney, n (%) | 385 (55) | 80 (41) | 35 (60) | < .0001 | 158 (45) | 227 (64) | < .001 |
| Creatinine > 1.5 mg/dL | 160 (24) | 62 (33) | 98 (21) | .0012 | 93 (28) | 67 (20) | .02 |
| Urine albumin > 3 g/d | 198 (29) | 35 (19) | 163 (33) | .0003 | 79 (23) | 119 (34) | .007 |
| Serum albumin < 3.5 g/dL | 575 (80) | 142 (74) | 433 (83) | .08 | 279 (78) | 296 (83) | .07 |
| Variable . | All patients . | Light-chain type . | dFLC . | ||||
|---|---|---|---|---|---|---|---|
| κ-restricted patients . | λ-restricted patients . | P . | High (> 19.6 mg/dL) . | Low (≤ 19.6 mg/dL) . | P . | ||
| Median κ FLC, mg/dL (range) | 1.6 (0.032-1360) | 31.4 (0.3-1360) | 1.2 (0.032-13) | NA | |||
| Median λ FLC, mg/dL (range) | 11.4 (0.06-2480) | 1.3 (0.06-24) | 19.4 (0.9-2480) | NA | |||
| κ:λ ratio abnormal, n (%) | 644 (88) | 191 (95) | 453 (86) | < .001 | |||
| Median dFLC, mg/dL (range) | 19.6 (0.01-2478) | 29.4 (0.01-1359) | 18.2 (0.03-2478) | < .001 | 56.2 (19.8-2478) | 7.8 (0.01-19.6) | NA |
| Median plasma cell % (range) | 8 (0-95) | 9.5 (1-95) | 8 (0-90) | .04 | 10 (2-95) | 6 (0-60) | < .001 |
| Heart, n (%) | 445 (65) | 109 (60) | 331 (67) | NS | 244 (71) | 196 (59) | < .001 |
| Septum > 12 mm | 423 (63) | 104 (58) | 316 (65) | .09 | 233 (69) | 187 (57) | .001 |
| EF < 50% | 151 (23) | 34 (19) | 117 (23) | NS | 100 (30) | 51 (16) | < .001 |
| cTnT > 0.035 ng/mL | 265 (44) | 60 (38) | 205 (47) | .05 | 154 (53) | 111 (36) | < .001 |
| NT-ProBNP > 332 pg/mL | 345 (70) | 96 (71) | 249 (70) | NS | 244 (71) | 196 (59) | < .001 |
| Liver, n (%) | 129 (20) | 57 (31) | 72 (16) | < .0001 | 65 (20) | 64 (20) | NS |
| Bilirubin > 1.5 mg/dL | 63 (10) | 23 (13) | 40 (9) | NS | 40 (12.5) | 23 (7) | .03 |
| Alk Phos > 1.5 × ULN | 118 (18) | 51 (28) | 67 (14) | .0002 | 59 (18) | 59 (18) | NS |
| Median serum carotene (range) | 126 (12-662) | 113 (12-370) | 130 (23-662) | .0006 | 107 (12-363) | 141 (36-662) | < .001 |
| Kidney, n (%) | 385 (55) | 80 (41) | 35 (60) | < .0001 | 158 (45) | 227 (64) | < .001 |
| Creatinine > 1.5 mg/dL | 160 (24) | 62 (33) | 98 (21) | .0012 | 93 (28) | 67 (20) | .02 |
| Urine albumin > 3 g/d | 198 (29) | 35 (19) | 163 (33) | .0003 | 79 (23) | 119 (34) | .007 |
| Serum albumin < 3.5 g/dL | 575 (80) | 142 (74) | 433 (83) | .08 | 279 (78) | 296 (83) | .07 |
The reference range for κFLC is 0.33-1.94 mg/dL, for λFLC is 0.57-2.63 mg/dL, and for the κ:λ ratio is 0.26-1.65.
NA indicates not applicable; and NS, not significant.