Multivariate analysis of the association of the DECTIN1 Y238X polymorphism with risk of invasive aspergillosis
| Genetic/clinical risk factors* . | Adjusted HR . | 95% CI . | P . |
|---|---|---|---|
| D Y238X + R WT | 2.50 | 1.00-6.53 | .05 |
| D WT + R Y238X | 1.51 | 0.46-4.93 | .49 |
| D Y238X + R Y238X | 3.89 | 1.51-9.99 | .005 |
| HLA haplotype mismatch | 2.70 | 1.31-5.56 | .007 |
| GVHD | 3.10 | 1.10-8.71 | .03 |
| Genetic/clinical risk factors* . | Adjusted HR . | 95% CI . | P . |
|---|---|---|---|
| D Y238X + R WT | 2.50 | 1.00-6.53 | .05 |
| D WT + R Y238X | 1.51 | 0.46-4.93 | .49 |
| D Y238X + R Y238X | 3.89 | 1.51-9.99 | .005 |
| HLA haplotype mismatch | 2.70 | 1.31-5.56 | .007 |
| GVHD | 3.10 | 1.10-8.71 | .03 |
D indicates donor; and R, recipient.
For the genetic factors, D WT + R WT genotype combination is the referent category; overall P value for the three-level DECTIN1 Y238X genotype is P = .019.