Clinical GVHD staging strategy
| Stage . | Skin . | Liver (bilirubin) . | Gastrointestinal tract . | Activity (inversely related to GVHD) . |
|---|---|---|---|---|
| 0 | No GVHD rash | < 4-fold increase over baseline | No diarrhea | Animal unable to respond normally to stimulation |
| 1 | Rash < 25% body surface area | 4- to 8-fold increase over baseline | “Mild” diarrhea with no other cause | Severely decreased or altered activity |
| 2 | Rash 25%-50% body surface area | 8- to 20-fold increase over baseline | “Moderate” diarrhea with no other cause | Moderately decreased or altered activity |
| 3 | Rash > 50% body surface area | 20- to 50-fold increase over baseline | “Severe” diarrhea with no other cause | Normal activity |
| 4 | Generalized erythroderma with bullous formation | > 50-fold increase over baseline | “Very severe” diarrhea with no other cause |
| Stage . | Skin . | Liver (bilirubin) . | Gastrointestinal tract . | Activity (inversely related to GVHD) . |
|---|---|---|---|---|
| 0 | No GVHD rash | < 4-fold increase over baseline | No diarrhea | Animal unable to respond normally to stimulation |
| 1 | Rash < 25% body surface area | 4- to 8-fold increase over baseline | “Mild” diarrhea with no other cause | Severely decreased or altered activity |
| 2 | Rash 25%-50% body surface area | 8- to 20-fold increase over baseline | “Moderate” diarrhea with no other cause | Moderately decreased or altered activity |
| 3 | Rash > 50% body surface area | 20- to 50-fold increase over baseline | “Severe” diarrhea with no other cause | Normal activity |
| 4 | Generalized erythroderma with bullous formation | > 50-fold increase over baseline | “Very severe” diarrhea with no other cause |
GVHD indicates graft-versus-host disease.