Hepcidin and iron disorders
| Disorder . | Genes mutated . | Hepcidin . |
|---|---|---|
| Hereditary hemochromatosis (hepcidin deficiency) | HFE, TfR2, HJV, hepcidin | Low or inappropriately normal, despite iron load |
| Hereditary hemochromatosis (hepcidin resistance) | Ferroportin | High, reflects iron load, rare |
| Ferroportin disease | Ferroportin | Insufficiently studied |
| Iron-refractory iron deficiency anemia | TMPRSS6 | High or inappropriately high normal, despite iron deficiency |
| Hypotransferrinemia | Transferrin | Low unless transfused with plasma |
| β-Thalassemia intermedia | β-Globin | Low unless transfused |
| Chronic hepatitis C, alcoholic liver disease | Decreased | |
| Anemia of inflammation | High or inappropriately normal, despite anemia and hypoferremia | |
| Anemia of chronic kidney diseases | High or inappropriately normal, despite anemia and hypoferremia |
| Disorder . | Genes mutated . | Hepcidin . |
|---|---|---|
| Hereditary hemochromatosis (hepcidin deficiency) | HFE, TfR2, HJV, hepcidin | Low or inappropriately normal, despite iron load |
| Hereditary hemochromatosis (hepcidin resistance) | Ferroportin | High, reflects iron load, rare |
| Ferroportin disease | Ferroportin | Insufficiently studied |
| Iron-refractory iron deficiency anemia | TMPRSS6 | High or inappropriately high normal, despite iron deficiency |
| Hypotransferrinemia | Transferrin | Low unless transfused with plasma |
| β-Thalassemia intermedia | β-Globin | Low unless transfused |
| Chronic hepatitis C, alcoholic liver disease | Decreased | |
| Anemia of inflammation | High or inappropriately normal, despite anemia and hypoferremia | |
| Anemia of chronic kidney diseases | High or inappropriately normal, despite anemia and hypoferremia |