Comparison of mean SF-36 scores between chronic GVHD (cGVHD) cohort members and US population normative data
| . | cGVHD patients* (n = 260) . | Normal population† (n = 260) . | Difference score (cGVHD patient minus age-sex–matched expected normal value) . | P‡ . | |||
|---|---|---|---|---|---|---|---|
| Mean . | SD . | Mean . | SD . | Mean . | SD . | ||
| Physical functioning | 40.94 | 10.83 | 49.56 | 2.84 | −8.61 | 10.65 | < .0001 |
| Role-physical | 36.80 | 11.46 | 49.71 | 2.24 | −12.91 | 11.61 | < .0001 |
| Bodily pain | 45.44 | 10.83 | 49.50 | 1.48 | −4.05 | 11.03 | .0042 |
| General health | 41.10 | 9.59 | 49.71 | 1.11 | −8.60 | 9.68 | < .0001 |
| Vitality | 45.65 | 10.86 | 50.77 | 1.50 | −5.11 | 11.12 | < .0001 |
| Social functioning | 40.28 | 12.30 | 50.15 | 0.85 | −9.87 | 12.32 | < .0001 |
| Role-emotional | 44.20 | 12.80 | 50.25 | 1.14 | −6.04 | 12.84 | .0621 |
| Mental health | 49.47 | 9.90 | 50.67 | 1.77 | −1.21 | 9.97 | .1536 |
| PCS | 38.99 | 9.69 | 49.33 | 2.67 | −10.34 | 9.84 | < .0001 |
| MCS | 48.05 | 10.59 | 50.83 | 1.83 | −2.78 | 10.65 | .6606 |
| . | cGVHD patients* (n = 260) . | Normal population† (n = 260) . | Difference score (cGVHD patient minus age-sex–matched expected normal value) . | P‡ . | |||
|---|---|---|---|---|---|---|---|
| Mean . | SD . | Mean . | SD . | Mean . | SD . | ||
| Physical functioning | 40.94 | 10.83 | 49.56 | 2.84 | −8.61 | 10.65 | < .0001 |
| Role-physical | 36.80 | 11.46 | 49.71 | 2.24 | −12.91 | 11.61 | < .0001 |
| Bodily pain | 45.44 | 10.83 | 49.50 | 1.48 | −4.05 | 11.03 | .0042 |
| General health | 41.10 | 9.59 | 49.71 | 1.11 | −8.60 | 9.68 | < .0001 |
| Vitality | 45.65 | 10.86 | 50.77 | 1.50 | −5.11 | 11.12 | < .0001 |
| Social functioning | 40.28 | 12.30 | 50.15 | 0.85 | −9.87 | 12.32 | < .0001 |
| Role-emotional | 44.20 | 12.80 | 50.25 | 1.14 | −6.04 | 12.84 | .0621 |
| Mental health | 49.47 | 9.90 | 50.67 | 1.77 | −1.21 | 9.97 | .1536 |
| PCS | 38.99 | 9.69 | 49.33 | 2.67 | −10.34 | 9.84 | < .0001 |
| MCS | 48.05 | 10.59 | 50.83 | 1.83 | −2.78 | 10.65 | .6606 |
Norm-based scores (mean = 50, SD = 10 based on the 1998 general US population).
Expected values for each cGVHD patient based on age and sex norm averages for the 1998 general US population. Expected physical functioning is slightly lower than 50 on average, and more variable for the patients, presumably due to associations with age.
Sign test (null hypothesis that it is equally likely that each cGVHD patient's score will be higher or lower than the age and sex norm).