Table 2 Analysis of miR155 signature in... | American Society of Hematology

Table 2

Analysis of miR155 signature in miR155^−/− BM-DCs

	Immature BM-DCs				Mature BM-DCs*
	Targets in up-regulated mRNAs†		Targets in down-regulated mRNAs†		Targets in up-regulated mRNAs†		Targets in down-regulated mRNAs†
	%	P	%	P	%	P‡	%	P
5% significance threshold for differential mRNA expression§
Seeds	22	.9	22	.9	37	10⁻⁶	19	.98
Conserved seeds	9.7	.6	4.7	1.0	15	.004	4	1.00
Targetscan 4	4.5	1.0	6.5	.8	12	.003	4	.99
ΔG duplex	1.2	.7	1.0	.7	2.4	.082	.4	.97
1% significance threshold for differential mRNA expression¶
Seeds	22	.7	28	.4	42	.001	27	.33
Conserved seeds	4.2	.9	4.8	.9	17	.024	5.1	.9
Targetscan 4	5.3	.7	7.1	.6	13	.08	10	.24
ΔG duplex	.0	1.0	1.6	.7	4.3	.14	0.0	1.0

	Immature BM-DCs				Mature BM-DCs*
	Targets in up-regulated mRNAs†		Targets in down-regulated mRNAs†		Targets in up-regulated mRNAs†		Targets in down-regulated mRNAs†
	%	P	%	P	%	P‡	%	P
5% significance threshold for differential mRNA expression§
Seeds	22	.9	22	.9	37	10⁻⁶	19	.98
Conserved seeds	9.7	.6	4.7	1.0	15	.004	4	1.00
Targetscan 4	4.5	1.0	6.5	.8	12	.003	4	.99
ΔG duplex	1.2	.7	1.0	.7	2.4	.082	.4	.97
1% significance threshold for differential mRNA expression¶
Seeds	22	.7	28	.4	42	.001	27	.33
Conserved seeds	4.2	.9	4.8	.9	17	.024	5.1	.9
Targetscan 4	5.3	.7	7.1	.6	13	.08	10	.24
ΔG duplex	.0	1.0	1.6	.7	4.3	.14	0.0	1.0

Treated with LPS for 24 hours.

Expression in miR155^−/− BM-DCs relative to WT BM-DCs.

One-sided Fisher test (bold indicates P < .05).

541 up-regulated mRNAs in miR155^−/− DCs (t test).

139 up-regulated mRNAs in miR155^−/− DCs (t test).