Table 2

NMZL gene expression signature: most relevant NMZL signature genes

GeneNMZL vs RLN comparison
NMZL vs FL comparison
Memory vs GC comparison
CytobandDescription
Fold changeFDRFold changeFDRFold changeP
TACI* 2.075 0.032 1.987 0.042 0.925 < .001 17p11.2 TNF receptor, B-cell stimulation. NF-κB activator 
CHIT1* 2.044 NS (0.072) 2.527 0.020 −0.234 NS 1q31-q32 Microenvironment involved 
CD82* 2.045 0.012 1.727 0.027 0.399 NS 11p11.2 Coactivator for the BCR pathway 
CHI3L1 1.588 0.028 1.635 0.029 0.133 ND 1q32.1 Microenvironment involved 
CLPTM1 1.652 0.009 1.334 0.049 0.249 ND 19q13.32 Lymphocyte activation 
PTPN1 1.487 0.008 1.243 0.026 0.245 ND 20q13.13 Signal transduction 
TRAF4 1.036 0.033 1.139 0.022 −0.110 ND 17q11.2 TNF receptor-associated factor; NF-κB activation 
TGF-β1* 1.175 0.010 1.009 0.025 0.371 NS 19q13.2 Cell proliferation and differentiation 
CD44* 0.874 0.029 1.285 0.006 1.131 NS 11p13 Adhesion molecule related to marginal zone 
SMAD2 −0.837 0.010 −0.712 0.030 0.000 ND 18q21.1 TGF-β signaling pathway 
HDAC2 −1.258 0.007 −1.016 0.013 −0.171 ND 6q22.1 Chromatin modification 
IKIP* −1.428 0.029 −1.270 0.045 −0.179 ND 12q23.1 Apoptosis 
RAD54B* −1.775 0.007 −1.291 0.026 −0.241 NS 8q22.1 DNA repair 
SMAD3 −2.447 0.029 −1.226 0.044 0.335 ND 6q23.1 TGF-β signaling pathway 
LMO2* −2.533 0.006 −1.732 0.014 −0.545 NS 11p13 GC marker 
LEF1 −2.828 0.009 −1.768 0.021 1.682 ND 4q25 Implicated in gene expression transcription 
CD10 −4.269 0.006 −2.172 0.041 −0.612 ND 3q32.31 GC marker 
GeneNMZL vs RLN comparison
NMZL vs FL comparison
Memory vs GC comparison
CytobandDescription
Fold changeFDRFold changeFDRFold changeP
TACI* 2.075 0.032 1.987 0.042 0.925 < .001 17p11.2 TNF receptor, B-cell stimulation. NF-κB activator 
CHIT1* 2.044 NS (0.072) 2.527 0.020 −0.234 NS 1q31-q32 Microenvironment involved 
CD82* 2.045 0.012 1.727 0.027 0.399 NS 11p11.2 Coactivator for the BCR pathway 
CHI3L1 1.588 0.028 1.635 0.029 0.133 ND 1q32.1 Microenvironment involved 
CLPTM1 1.652 0.009 1.334 0.049 0.249 ND 19q13.32 Lymphocyte activation 
PTPN1 1.487 0.008 1.243 0.026 0.245 ND 20q13.13 Signal transduction 
TRAF4 1.036 0.033 1.139 0.022 −0.110 ND 17q11.2 TNF receptor-associated factor; NF-κB activation 
TGF-β1* 1.175 0.010 1.009 0.025 0.371 NS 19q13.2 Cell proliferation and differentiation 
CD44* 0.874 0.029 1.285 0.006 1.131 NS 11p13 Adhesion molecule related to marginal zone 
SMAD2 −0.837 0.010 −0.712 0.030 0.000 ND 18q21.1 TGF-β signaling pathway 
HDAC2 −1.258 0.007 −1.016 0.013 −0.171 ND 6q22.1 Chromatin modification 
IKIP* −1.428 0.029 −1.270 0.045 −0.179 ND 12q23.1 Apoptosis 
RAD54B* −1.775 0.007 −1.291 0.026 −0.241 NS 8q22.1 DNA repair 
SMAD3 −2.447 0.029 −1.226 0.044 0.335 ND 6q23.1 TGF-β signaling pathway 
LMO2* −2.533 0.006 −1.732 0.014 −0.545 NS 11p13 GC marker 
LEF1 −2.828 0.009 −1.768 0.021 1.682 ND 4q25 Implicated in gene expression transcription 
CD10 −4.269 0.006 −2.172 0.041 −0.612 ND 3q32.31 GC marker 

Fold changes corresponding to the log2 difference between the NMZL and RLN, NMZL, and FL, and memory B-cell and GC B-cell averages, respectively. FDR and P values are from the t test (http://pomelo2.bioinfo.cnio.es/).

NS indicates not significant; and ND, not determined.

*

To validate the microarray data, the gene was included in the quantitative RT-PCR assay.

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