GSEA for NMZL gene expression profile
| Gene sets . | P . | FDR . | Up-regulated genes . |
|---|---|---|---|
| IL6 pathway | .004 | 0.177 | SHC1, JAK1, CSNK2A1, RAF1, STAT3, JUN, HRAS, MAPK3, GRB2 |
| Integrin pathway | .006 | 0.135 | BCR, RAF1, ZYX, JUN, CAPNS1, CSK, MAP2K2, HRAS, MAPK3, GRB2, RAPGEF1, CAPN1 |
| IL2RB pathway | .004 | 0.152 | SHC1, PTPN6, IL2RA, JAK1, SYK, RAF1, CFLAR, SOCS1, BAD, AKT1, BCL2L1, HRAS, MAPK3, IKZF3, GRB2, CSNK2A1, JUN |
| CD40 signaling during GC development | .028 | 0.202 | KCNN4, BTG2, CAPG, LYN, LITAF, IRF5, DUSP2, JUNB, CD44, IRF4, CD74, NF-KB2, IFI30, ADAM8, TNF |
| RAC and CYCD pathway | .021 | 0.210 | RELA, HRAS, MAPK3, CDKN1A, AKT1, RAF1, CDK4 |
| TGF-β pathway | .023 | 0.210 | MAP3K7IP1, EP300, MAPK3, TGF-β1 |
| PTD INS pathway | .028 | 0.195 | PFKM, GSK3B, VAV2, AP2A1, BAD, AKT1, PFKL, ARF1, AP2M1, LYN |
| IL2 pathway | .030 | 0.197 | SHC1, PTPN6, IL2RA, JAK1, SYK, RAF1, CFLAR, SOCS1, BAD, AKT1, BCL2L1, HRAS, MAPK3, IKZF3, GRB2, CSNK2A1, JUN |
| RELA pathway | .042 | 0.203 | RELA, EP300, IKBKG, TNF, HDAC3, FADD, TRADD |
| TNFR1 pathway | .023 | 0.214 | MADD, JUN, LMNA, DFFB, SPTAN1, CASP2, PRKDC, TNF, TRADD, ARHGDIB, MAP3K1, FADD |
| Gene sets . | P . | FDR . | Up-regulated genes . |
|---|---|---|---|
| IL6 pathway | .004 | 0.177 | SHC1, JAK1, CSNK2A1, RAF1, STAT3, JUN, HRAS, MAPK3, GRB2 |
| Integrin pathway | .006 | 0.135 | BCR, RAF1, ZYX, JUN, CAPNS1, CSK, MAP2K2, HRAS, MAPK3, GRB2, RAPGEF1, CAPN1 |
| IL2RB pathway | .004 | 0.152 | SHC1, PTPN6, IL2RA, JAK1, SYK, RAF1, CFLAR, SOCS1, BAD, AKT1, BCL2L1, HRAS, MAPK3, IKZF3, GRB2, CSNK2A1, JUN |
| CD40 signaling during GC development | .028 | 0.202 | KCNN4, BTG2, CAPG, LYN, LITAF, IRF5, DUSP2, JUNB, CD44, IRF4, CD74, NF-KB2, IFI30, ADAM8, TNF |
| RAC and CYCD pathway | .021 | 0.210 | RELA, HRAS, MAPK3, CDKN1A, AKT1, RAF1, CDK4 |
| TGF-β pathway | .023 | 0.210 | MAP3K7IP1, EP300, MAPK3, TGF-β1 |
| PTD INS pathway | .028 | 0.195 | PFKM, GSK3B, VAV2, AP2A1, BAD, AKT1, PFKL, ARF1, AP2M1, LYN |
| IL2 pathway | .030 | 0.197 | SHC1, PTPN6, IL2RA, JAK1, SYK, RAF1, CFLAR, SOCS1, BAD, AKT1, BCL2L1, HRAS, MAPK3, IKZF3, GRB2, CSNK2A1, JUN |
| RELA pathway | .042 | 0.203 | RELA, EP300, IKBKG, TNF, HDAC3, FADD, TRADD |
| TNFR1 pathway | .023 | 0.214 | MADD, JUN, LMNA, DFFB, SPTAN1, CASP2, PRKDC, TNF, TRADD, ARHGDIB, MAP3K1, FADD |
The gene sets were considered up-regulated values of P < .05 and FDR < 0.250 in GSEA analysis using a t test.