Association statistics for lead SNPs
| Gene context . | SNP . | Band . | Position . | Alleles . | Dose.b . | MPN . | V617F+ . | Combined . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| P . | OR . | P . | OR . | P . | OR . | ||||||
| [JAK2] | rs59384377 | 9p24.1 | 5005034 | A/T | 0.265 | 4.3e-57 | 2.46 | 3.8e-35 | 2.33 | 6.6e-89 | 2.41 |
| [TERT] | rs7705526 | 5p15.33 | 1285974 | C/A | 0.436 | 2.5e-16 | 1.69 | 1.3e-18 | 1.96 | 2.9e-32 | 1.80 |
| [TERT] | rs2853677 | 5p15.33 | 1287194 | A/G | 0.355 | 5.2e-16 | 1.56 | 9.3e-19 | 1.80 | 5.2e-32 | 1.65 |
| [SH2B3] | rs7310615 | 12q24.12 | 111865049 | G/C | 0.509 | 5.3e-07 | 1.32 | 2.5e-09 | 1.50 | 3.1e-14 | 1.39 |
| CXXC4—[]—TET2 | rs1548483 | 4q24 | 105749895 | C/T | 0.037 | 1.6e-07 | 2.12 | .0019 | 1.75 | 2.0e-09 | 1.97 |
| [CHEK2] | rs555607708 | 22q12.1 | 29091857 | I/D | 0.002 | 1.1e-05 | 4.49 | .0015 | 4.07 | 7.5e-08 | 4.35 |
| [ATM] | rs1800056 | 11q22.3 | 108138003 | T/C | 0.014 | 1.2e-05 | 2.18 | .011 | 1.78 | 6.5e-07 | 2.02 |
| [PINT] | rs58270997 | 7q32.3 | 130729394 | C/T | 0.267 | 1.8e-06 | 1.43 | .0079 | 1.27 | 1.1e-07 | 1.36 |
| GFI1B-[]–GTF3C5 | rs621940 | 9q34.13 | 135870130 | C/G | 0.160 | 1.2e-05 | 1.35 | .0031 | 1.28 | 1.9e-07 | 1.32 |
| Gene context . | SNP . | Band . | Position . | Alleles . | Dose.b . | MPN . | V617F+ . | Combined . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| P . | OR . | P . | OR . | P . | OR . | ||||||
| [JAK2] | rs59384377 | 9p24.1 | 5005034 | A/T | 0.265 | 4.3e-57 | 2.46 | 3.8e-35 | 2.33 | 6.6e-89 | 2.41 |
| [TERT] | rs7705526 | 5p15.33 | 1285974 | C/A | 0.436 | 2.5e-16 | 1.69 | 1.3e-18 | 1.96 | 2.9e-32 | 1.80 |
| [TERT] | rs2853677 | 5p15.33 | 1287194 | A/G | 0.355 | 5.2e-16 | 1.56 | 9.3e-19 | 1.80 | 5.2e-32 | 1.65 |
| [SH2B3] | rs7310615 | 12q24.12 | 111865049 | G/C | 0.509 | 5.3e-07 | 1.32 | 2.5e-09 | 1.50 | 3.1e-14 | 1.39 |
| CXXC4—[]—TET2 | rs1548483 | 4q24 | 105749895 | C/T | 0.037 | 1.6e-07 | 2.12 | .0019 | 1.75 | 2.0e-09 | 1.97 |
| [CHEK2] | rs555607708 | 22q12.1 | 29091857 | I/D | 0.002 | 1.1e-05 | 4.49 | .0015 | 4.07 | 7.5e-08 | 4.35 |
| [ATM] | rs1800056 | 11q22.3 | 108138003 | T/C | 0.014 | 1.2e-05 | 2.18 | .011 | 1.78 | 6.5e-07 | 2.02 |
| [PINT] | rs58270997 | 7q32.3 | 130729394 | C/T | 0.267 | 1.8e-06 | 1.43 | .0079 | 1.27 | 1.1e-07 | 1.36 |
| GFI1B-[]–GTF3C5 | rs621940 | 9q34.13 | 135870130 | C/G | 0.160 | 1.2e-05 | 1.35 | .0031 | 1.28 | 1.9e-07 | 1.32 |
Band, cytogenetic band; position, chromosomal position in National Center for Biotechnology Information Build 37 coordinates; dose.b, average imputed dosage for the second listed allele; gene context, a representation of the gene(s) flanking the SNP position; I/D, insertion/deletion; P, the SNP association test P value.