Replication cohort results for lead SNPs
| SNP . | OR . | 95% CI . | P . | Joint P* . |
|---|---|---|---|---|
| JAK2 rs59384377 | 2.04 | [1.78,2.32] | 2.3e-24 | 3.9e-110 |
| TERT rs7705526 | 1.70 | [1.47,1.97] | 2.1e-12 | 6.2e-42 |
| TERT rs2853677 | 1.70 | [1.49,1.95] | 6.2e-15 | 3.4e-44 |
| SH2B3 rs7310615 | 1.30 | [1.14,1.49] | .00011 | 1.4e-16 |
| TET2 rs1548483 | 1.89 | [1.41,2.54] | 8.7e-05 | 5.3e-12 |
| CHEK2 rs555607708 | 4.89 | [2.41,9.91] | .00042 | 7.8e-10 |
| ATM rs1800056 | 1.96 | [1.30,2.94] | .0035 | 4.7e-8 |
| PINT rs58270997 | 1.40 | [1.20,1.65] | 4.2e-5 | 1.2e-10 |
| GFI1B rs621940 | 1.34 | [1.14,1.59] | .00070 | 3.2e-9 |
| SNP . | OR . | 95% CI . | P . | Joint P* . |
|---|---|---|---|---|
| JAK2 rs59384377 | 2.04 | [1.78,2.32] | 2.3e-24 | 3.9e-110 |
| TERT rs7705526 | 1.70 | [1.47,1.97] | 2.1e-12 | 6.2e-42 |
| TERT rs2853677 | 1.70 | [1.49,1.95] | 6.2e-15 | 3.4e-44 |
| SH2B3 rs7310615 | 1.30 | [1.14,1.49] | .00011 | 1.4e-16 |
| TET2 rs1548483 | 1.89 | [1.41,2.54] | 8.7e-05 | 5.3e-12 |
| CHEK2 rs555607708 | 4.89 | [2.41,9.91] | .00042 | 7.8e-10 |
| ATM rs1800056 | 1.96 | [1.30,2.94] | .0035 | 4.7e-8 |
| PINT rs58270997 | 1.40 | [1.20,1.65] | 4.2e-5 | 1.2e-10 |
| GFI1B rs621940 | 1.34 | [1.14,1.59] | .00070 | 3.2e-9 |
OR, odds ratio for the GWAS risk allele in the replication cohort; P, association test P value in the replication cohort.
Joint P: overall test of combined GWAS results (Table 2) and replication cohort results using Fisher’s method.