MicroRNAs altered in MSCs by myeloma
| miR name . | Fc, 3D model (MSCs in coculture with MM1S vs alone) . | P value, 3D model (MSCs in coculture with MM1S vs alone) . | Fc, MM vs ND MSCs . | P value, MM vs ND MSCs . |
|---|---|---|---|---|
| hsa-miR-199a-5p | –2.019 | .00086974 | –1.917 | .00115665 |
| hsa-miR-181a-5p | 1.771 | .00362835 | 3.190 | .02106839 |
| hsa-miR-181c-5p | 2.135 | .00276756 | 3.078 | .00192591 |
| hsa-miR-222-3p | 2.152 | .00332040 | 1.821 | .01680615 |
| hsa-miR-601 | 2.546 | .00738047 | 3.637 | .02449335 |
| hsa-miR-146a-5p | 17.175 | .00405939 | 15.353 | .02622689 |
| miR name . | Fc, 3D model (MSCs in coculture with MM1S vs alone) . | P value, 3D model (MSCs in coculture with MM1S vs alone) . | Fc, MM vs ND MSCs . | P value, MM vs ND MSCs . |
|---|---|---|---|---|
| hsa-miR-199a-5p | –2.019 | .00086974 | –1.917 | .00115665 |
| hsa-miR-181a-5p | 1.771 | .00362835 | 3.190 | .02106839 |
| hsa-miR-181c-5p | 2.135 | .00276756 | 3.078 | .00192591 |
| hsa-miR-222-3p | 2.152 | .00332040 | 1.821 | .01680615 |
| hsa-miR-601 | 2.546 | .00738047 | 3.637 | .02449335 |
| hsa-miR-146a-5p | 17.175 | .00405939 | 15.353 | .02622689 |
Six miRs were found to be similarly upregulated (5 miRs) or downregulated (1 miRs) in the 3D system (MSCs cocultured with GFP+MM1S vs MSCs alone, after 2 weeks in coculture in osteogenic, no-dexamethasone media) and in patient vs normal samples (MM patient MSCs vs normal donor MSCs). Fc ≥1.5, P < .05, n ≥3, 2-tailed Student's t test, average expression >25 nanoString counts.